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伴有印戒细胞的子宫内膜HPV11阳性子宫内膜样癌：诊断标准及文献综述

HPV11 Positive Endometrioid Carcinoma of the Endometrium with Signet-Ring Cells: Diagnostic Criteria and Review of the Literature.

作者信息

Pusiol Teresa

机构信息

Institute of Anatomic Pathology, Rovereto Hospital, Rovereto, 38060 Trento, Italy.

出版信息

Case Rep Pathol. 2014;2014:380571. doi: 10.1155/2014/380571. Epub 2014 Apr 7.

DOI:10.1155/2014/380571
PMID:24804134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3997913/
Abstract

The presence of signet-ring cells in an endometrial adenocarcinoma is extremely uncommon and it is always necessary to rule out a metastatic neoplasm. We report a FIGO grade 2 endometrial carcinoma with a signet-ring cell component found in the curettage performed to a 53-year-old woman. The neoplastic proliferation was also found in the endometrium of the radical hysterectomy with bilateral salpingo-oophorectomy and pelvic and para-aortic lymphadenectomy. The uterine neoplasm invaded less than one-half of the myometrium (FIGO stage I B). Alcian blue showed the presence of mucin in the signet-ring cells. The patient was alive and without evidence of recurrence 14 months after surgery. Polymerase chain reaction method from paraffin-embedded tissue revealed the presence of human papilloma virus type 11. We have discussed the differential diagnosis of this kind of neoplasm and we have reviewed the literature on signet-ring cell carcinoma of the endometrium.

摘要

在子宫内膜腺癌中出现印戒细胞极为罕见，因此始终有必要排除转移性肿瘤。我们报告了一例在对一名53岁女性进行刮宫时发现的具有印戒细胞成分的国际妇产科联盟（FIGO）2级子宫内膜癌。在根治性子宫切除术加双侧输卵管卵巢切除术以及盆腔和腹主动脉旁淋巴结清扫术中，子宫内膜也发现了肿瘤增殖。子宫肿瘤侵犯肌层不到一半（FIGO I B期）。阿尔辛蓝染色显示印戒细胞中存在粘蛋白。患者术后14个月存活，无复发迹象。石蜡包埋组织的聚合酶链反应方法显示存在11型人乳头瘤病毒。我们讨论了这类肿瘤的鉴别诊断，并回顾了有关子宫内膜印戒细胞癌的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/a89b5255dd60/CRIPA2014-380571.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/a73b71220621/CRIPA2014-380571.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/b86b0bd56d2c/CRIPA2014-380571.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/a89b5255dd60/CRIPA2014-380571.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/a73b71220621/CRIPA2014-380571.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/50f32df417c8/CRIPA2014-380571.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/f79e4b211d87/CRIPA2014-380571.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/6867f9288042/CRIPA2014-380571.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/b86b0bd56d2c/CRIPA2014-380571.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6918/3997913/a89b5255dd60/CRIPA2014-380571.006.jpg

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本文引用的文献

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Association between human papillomavirus and endometrial adenocarcinoma.人乳头瘤病毒与子宫内膜腺癌的关系。
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2
Immunohistochemistry and HPV in situ hybridization in pathologic distinction between endocervical and endometrial adenocarcinoma: a comparative tissue microarray study of 76 tumors.免疫组织化学和 HPV 原位杂交在鉴别宫颈内膜腺癌和子宫内膜腺癌中的应用：76 例肿瘤的组织微阵列比较研究。
Int J Gynecol Cancer. 2013 Feb;23(2):380-4. doi: 10.1097/IGC.0b013e31825cc8ee.
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p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma.
p16 表达与膀胱鳞状细胞癌中的人乳头瘤病毒无关。
Mod Pathol. 2012 Nov;25(11):1526-33. doi: 10.1038/modpathol.2012.103. Epub 2012 Jun 8.
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The relationship between p16 expression and high-risk human papillomavirus infection in squamous cell carcinomas from sites other than uterine cervix: a study of 137 cases.p16 表达与宫颈外鳞癌中高危型人乳头瘤病毒感染的关系：137 例研究。
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Endometrial adenocarcinoma with signet ring cells: report of two cases of an extremely rare phenomenon.伴有印戒细胞的子宫内膜腺癌：极为罕见现象的两例报告。
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