Hording U, Daugaard S, Visfeldt J
Department of Gynecology and Obstetrics, University Hospital Copenhagen, Denmark.
APMIS. 1997 Apr;105(4):313-6. doi: 10.1111/j.1699-0463.1997.tb00575.x.
The differential diagnosis between primary endocervical adenocarcinoma and adenocarcinoma originating in the endometrium may in some cases be difficult. The two cancer types have a different genesis, with human papillomavirus (HPV) as an important causal factor in the development of primary cervical carcinoma. In this study, the paraffin-embedded cervical tissues from 23 patients with stage II endometrial carcinoma and from 50 patients with primary cervical adenocarcinoma were examined for HPV DNA of types 16, 18, and 33. HPV DNA was demonstrated in 70% of the primary endocervical adenocarcinomas and in none of the endometrial carcinomas. It is concluded that HPV detection may be useful in the differential diagnosis of some cases of cervical and endometrial adenocarcinoma.
原发性宫颈腺癌与子宫内膜起源的腺癌之间的鉴别诊断在某些情况下可能很困难。这两种癌症类型有不同的起源，人乳头瘤病毒（HPV）是原发性宫颈癌发生的一个重要致病因素。在本研究中，对23例II期子宫内膜癌患者和50例原发性宫颈腺癌患者的石蜡包埋宫颈组织进行了16、18和33型HPV DNA检测。70%的原发性宫颈腺癌中检测到HPV DNA，而子宫内膜癌中均未检测到。结论是，HPV检测可能有助于某些宫颈和子宫内膜腺癌病例的鉴别诊断。
