Taylor R G, Verity K, Fuller P J
Department of Surgery, Royal Children's Hospital, Parkville, Australia.
Gastroenterology. 1990 Sep;99(3):724-9. doi: 10.1016/0016-5085(90)90961-y.
Massive small bowel resection with re-anastomosis of the residual jejunum and terminal ileum results in marked adaptive responses. Various luminal and humoral factors have been implicated in the adaptive response, which may be analogous to the changes occurring in the ileum in the postnatal growth phase. Enteroglucagon, which is synthesized in the L cells of the intestinal mucosa, is thought to be an important humoral factor in this response. In this study, the levels of glucagon gene expression in the rat ileum both after massive small bowel resection and during development are examined. Glucagon messenger RNA levels are increased threefold as part of the adaptive response; the increase is maximal at 2 days and is at least partly dependent on luminal nutrition. Levels of glucagon messenger RNA in the developing ileum increase in the postnatal period until weaning when they decrease somewhat before gradually reaching adult levels.
大量小肠切除并将残余空肠和回肠末端重新吻合会导致显著的适应性反应。各种管腔和体液因素都与这种适应性反应有关，这可能类似于出生后生长阶段回肠中发生的变化。肠高血糖素在肠黏膜的L细胞中合成，被认为是这种反应中的一种重要体液因素。在本研究中，检测了大鼠回肠在大量小肠切除后以及发育过程中的胰高血糖素基因表达水平。作为适应性反应的一部分，胰高血糖素信使核糖核酸水平增加了三倍；这种增加在术后2天达到最大值，并且至少部分依赖于管腔营养。发育中的回肠中胰高血糖素信使核糖核酸水平在出生后直至断奶期间升高，断奶时略有下降，然后逐渐达到成年水平。
