Easley Deidra, Tillman Emma
Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee ; The Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee.
J Pediatr Pharmacol Ther. 2013 Apr;18(2):105-11. doi: 10.5863/1551-6776-18.2.105.
Hypotonic intravenous (IV) fluids in children are a mainstay of therapy based on a recommendation made in 1957 by Holliday and Segar. Since that time, hospital-acquired hyponatremia caused by hypotonic IV fluids has been found to be an additional risk factor in the cause of death and neurological impairment in acutely ill children. This article reviews and critically evaluates the literature regarding the association of hyponatremia and hypotonic IV fluids in pediatric hospitalized, postoperative, and critical care patients.
基于1957年霍利迪(Holliday)和西加尔(Segar)提出的建议,低渗静脉输液一直是儿童治疗的主要手段。自那时起,人们发现低渗静脉输液导致的医院获得性低钠血症是急性病患儿死亡和神经功能损害的一个额外危险因素。本文回顾并批判性地评估了有关儿科住院患者、术后患者及重症监护患者低钠血症与低渗静脉输液之间关联的文献。