Sadeghi Masoumeh, Ghashghaei Fatemeh E, Rabiei Katayoun, Roohafza Hamidreza, Afshar Hamid
Cardiac Rehabilitation Research Center, Isfahan Cardiovascular, Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2012 Aug;17(8):787-91.
Coronary artery disease (CAD) is the leading cause of death and disability all over the world. A sedentary lifestyle and dyslipidemia are known to be the major risk factors, which play an important role in the progression of coronary artery disease. Regarding gender differences, the risk of developing coronary heart disease is recognized as being different between non-obese males and non-obese females. Hence, the aim of this study is to assess the benefits of a comprehensive cardiac rehabilitation program (CRP) on the functional capacity and lipid profiles, such as, total cholesterol, triglycerides, low density lipoprotein cholesterol, and high density lipoprotein cholesterol in non-obese males and non-obese females with coronary artery disease, and comparing these groups.
We evaluated 585 non-obese males and females with coronary artery disease. All the participants completed the cardiac rehabilitation program for two months, which included 24 exercise training sessions, medical evaluation, and consultation. For investigation of the effects of the cardiac rehabilitation program on the functional capacity and lipid profiles, exercise tests were carried out by each patient, and also, their blood samples were taken on entrance and at the end of this period.
The findings, following 24 sessions in the cardiac rehabilitation program, showed that the functional capacity (P = 0.00) and all lipid profiles had significantly improved in both the groups, except that the high density lipoprotein cholesterol did not show a significant difference in non-obese females. In addition, comparing the two groups did not show any significant differences in lipid profiles, but the changes in functional capacity were significant (P = 0.00) between the two groups, following the cardiac rehabilitation program.
The CRP, which was performed by the patients under supervision of a physician and an exercise physiologist, plays a key role in improving the functional capacity (FC) and all lipid profiles in non-obese males and females with coronary artery disease, without any attention to gender differences.
冠状动脉疾病（CAD）是全球死亡和残疾的主要原因。久坐不动的生活方式和血脂异常是已知的主要风险因素，在冠状动脉疾病的进展中起重要作用。关于性别差异，非肥胖男性和非肥胖女性患冠心病的风险被认为有所不同。因此，本研究的目的是评估综合心脏康复计划（CRP）对患有冠状动脉疾病的非肥胖男性和非肥胖女性的功能能力和血脂谱（如总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇）的益处，并对这些组进行比较。
我们评估了585名患有冠状动脉疾病的非肥胖男性和女性。所有参与者完成了为期两个月的心脏康复计划，其中包括24次运动训练课程、医学评估和咨询。为了研究心脏康复计划对功能能力和血脂谱的影响，每位患者都进行了运动测试，并且在入组时和该阶段结束时采集了他们的血样。
在心脏康复计划进行24次课程后，结果显示两组的功能能力（P = 0.00）和所有血脂谱均有显著改善，但非肥胖女性的高密度脂蛋白胆固醇没有显著差异。此外，比较两组血脂谱没有显示出任何显著差异，但在心脏康复计划后，两组之间的功能能力变化显著（P = 0.00）。
由医生和运动生理学家监督患者进行的CRP，在改善患有冠状动脉疾病的非肥胖男性和女性的功能能力（FC）和所有血脂谱方面起着关键作用，而无需关注性别差异。
