RAS 信号通路、突变及其在结直肠癌中的作用。
RAS signaling pathways, mutations and their role in colorectal cancer.
机构信息
Kypros Zenonos, Katy Kyprianou, College of Medical and Dental Sciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom.
出版信息
World J Gastrointest Oncol. 2013 May 15;5(5):97-101. doi: 10.4251/wjgo.v5.i5.97.
Abstract
Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, these are important in controlling several functions, such as cell growth and survival. It becomes self-evident that these events will be disrupted in a malignant cell with a deregulated MAPK or PI3K pathway. Mutations in genes involved in these pathways and interacting with RAS, as well as RAS itself will be discussed. The second part of this review concentrates on how crucial RAS signaling is in colorectal cancer progression, with references to treatment response and prognosis when RAS or other related mutations are present.
摘要
RAS 蛋白作用的两个主要细胞途径是丝裂原活化蛋白激酶（MAPK）和磷酸肌醇 3 激酶（PI3K）途径。在正常细胞中，这些途径对于控制细胞生长和存活等多种功能非常重要。显然，在 MAPK 或 PI3K 途径失调的恶性细胞中，这些事件将会被打乱。本文将讨论涉及这些途径并与 RAS 相互作用的基因以及 RAS 本身的突变。本综述的第二部分集中讨论 RAS 信号在结直肠癌进展中的重要性，并参考了存在 RAS 或其他相关突变时的治疗反应和预后。
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