中药治疗食物过敏反应：从动物模型到人体临床试验。
Treatment of food anaphylaxis with traditional Chinese herbal remedies: from mouse model to human clinical trials.
机构信息
Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):386-91. doi: 10.1097/ACI.0b013e3283615bc4.
Abstract
PURPOSE OF REVIEW
To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine.
RECENT FINDINGS
FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges.
SUMMARY
FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies.
摘要
目的综述
描述一种新型食物过敏治疗方法的发展，该方法基于中药，名为食物过敏草药配方-2（FAHF-2）。
最新发现
FAHF-2 已被证明在治疗花生和多种食物过敏的小鼠模型中耐受良好且有效。这些结果伴随着有利的免疫调节的证据，并且在停止治疗后效果仍然持久。早期临床试验表明，该配方在食物过敏个体中具有安全性和耐受性。正在进行的 II 期临床试验将评估 FAHF-2 在保护个体免受口服食物挑战引起的过敏反应中的功效。
总结
FAHF-2 是一种草药配方，具有很高的安全性，已显示可预防食物过敏小鼠模型中的过敏反应。临床试验中的类似发现可能为食物过敏带来新的治疗方法。
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