• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Treatment of food anaphylaxis with traditional Chinese herbal remedies: from mouse model to human clinical trials.中药治疗食物过敏反应：从动物模型到人体临床试验。
Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):386-91. doi: 10.1097/ACI.0b013e3283615bc4.
2
Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy.一种用于食物过敏的中药（食物过敏中药配方-2）的安全性、临床及免疫疗效
J Allergy Clin Immunol. 2015 Oct;136(4):962-970.e1. doi: 10.1016/j.jaci.2015.04.029. Epub 2015 Jun 1.
3
Chinese herbal therapy for the treatment of food allergy.中药治疗食物过敏。
Curr Allergy Asthma Rep. 2012 Aug;12(4):332-8. doi: 10.1007/s11882-012-0265-4.
4
The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy.中药配方FAHF-2在花生过敏小鼠模型中完全阻断过敏反应。
J Allergy Clin Immunol. 2005 Jan;115(1):171-8. doi: 10.1016/j.jaci.2004.10.003.
5
Efficacy and immunological actions of FAHF-2 in a murine model of multiple food allergies.FAHF-2 在多发性食物过敏小鼠模型中的疗效和免疫作用。
Ann Allergy Asthma Immunol. 2012 May;108(5):351-358.e1. doi: 10.1016/j.anai.2012.03.008.
6
Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model.食物过敏草药配方-1（FAHF-1）在小鼠模型中可阻断花生诱导的过敏反应。
J Allergy Clin Immunol. 2001 Oct;108(4):639-46. doi: 10.1067/mai.2001.118787.
7
Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils.食物过敏草药配方 2 可通过抑制肥大细胞和嗜碱性粒细胞来预防花生过敏反应。
J Allergy Clin Immunol. 2010 Dec;126(6):1208-17.e3. doi: 10.1016/j.jaci.2010.09.013.
8
Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy.食物过敏草药配方2（FAHF-2）中各味草药对花生过敏的药理及免疫作用。
Phytother Res. 2008 May;22(5):651-9. doi: 10.1002/ptr.2357.
9
Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells.食物过敏草药配方2通过产生干扰素-γ的CD8 + T细胞在治疗后较长时间内抑制花生诱导的过敏反应。
J Allergy Clin Immunol. 2009 Feb;123(2):443-51. doi: 10.1016/j.jaci.2008.12.1107.
10
Berberine as a chemical and pharmacokinetic marker of the butanol-extracted Food Allergy Herbal Formula-2.小檗碱作为丁醇提取食物过敏草药配方 2 的化学和药代动力学标志物。
Int Immunopharmacol. 2017 Apr;45:120-127. doi: 10.1016/j.intimp.2017.01.009. Epub 2017 Feb 14.

引用本文的文献

1
Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.基于网络药理学策略探索京银颗粒抗肺纤维化的机制
Front Pharmacol. 2022 Feb 11;13:825667. doi: 10.3389/fphar.2022.825667. eCollection 2022.
2
Butanol Purified Food Allergy Herbal Formula-2 Has an Immunomodulating Effect in Pediatric Crohn's Disease Subjects.丁醇纯化食品过敏草药配方-2对小儿克罗恩病患者具有免疫调节作用。
Front Med (Lausanne). 2021 Nov 29;8:782859. doi: 10.3389/fmed.2021.782859. eCollection 2021.
3
Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases.工程化微生物组：过敏性和自身免疫性疾病免疫治疗的新方法。
Curr Allergy Asthma Rep. 2015 Jul;15(7):39. doi: 10.1007/s11882-015-0538-9.
4
Food allergy: Insights into etiology, prevention, and treatment provided by murine models.食物过敏：鼠模型提供的病因、预防和治疗的新见解。
J Allergy Clin Immunol. 2014 Feb;133(2):309-17. doi: 10.1016/j.jaci.2013.12.1045.

本文引用的文献

1
Efficacy and immunological actions of FAHF-2 in a murine model of multiple food allergies.FAHF-2 在多发性食物过敏小鼠模型中的疗效和免疫作用。
Ann Allergy Asthma Immunol. 2012 May;108(5):351-358.e1. doi: 10.1016/j.anai.2012.03.008.
2
Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study.食物过敏草药配方-2（FAHF-2）的临床安全性及对食物过敏患者嗜碱性粒细胞的抑制作用：扩展的 I 期研究。
J Allergy Clin Immunol. 2011 Dec;128(6):1259-1265.e2. doi: 10.1016/j.jaci.2011.06.015. Epub 2011 Jul 26.
3
The prevalence, severity, and distribution of childhood food allergy in the United States.美国儿童食物过敏的流行率、严重程度和分布情况。
Pediatrics. 2011 Jul;128(1):e9-17. doi: 10.1542/peds.2011-0204. Epub 2011 Jun 20.
4
Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils.食物过敏草药配方 2 可通过抑制肥大细胞和嗜碱性粒细胞来预防花生过敏反应。
J Allergy Clin Immunol. 2010 Dec;126(6):1208-17.e3. doi: 10.1016/j.jaci.2010.09.013.
5
Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report.美国食物过敏诊断与管理指南：美国国立过敏与传染病研究所资助的专家小组报告摘要
J Allergy Clin Immunol. 2010 Dec;126(6):1105-18. doi: 10.1016/j.jaci.2010.10.008.
6
Efficacy, safety and immunological actions of butanol-extracted Food Allergy Herbal Formula-2 on peanut anaphylaxis.柏子仁二味方对花生过敏的疗效、安全性和免疫作用。
Clin Exp Allergy. 2011 Apr;41(4):582-91. doi: 10.1111/j.1365-2222.2010.03643.x. Epub 2010 Dec 1.
7
National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006.全国食物过敏的流行情况和危险因素及其与哮喘的关系：来自 2005-2006 年全国健康和营养调查的结果。
J Allergy Clin Immunol. 2010 Oct;126(4):798-806.e13. doi: 10.1016/j.jaci.2010.07.026.
8
Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study.一种食物过敏草本配方在食物过敏个体中的安全性、耐受性和免疫效果：一项随机、双盲、安慰剂对照、剂量递增、1 期研究。
Ann Allergy Asthma Immunol. 2010 Jul;105(1):75-84. doi: 10.1016/j.anai.2010.05.005.
9
Complementary and alternative medicine use among adults and children: United States, 2007.2007年美国成人和儿童使用补充与替代医学的情况
Natl Health Stat Report. 2008 Dec 10(12):1-23.
10
Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells.食物过敏草药配方2通过产生干扰素-γ的CD8 + T细胞在治疗后较长时间内抑制花生诱导的过敏反应。
J Allergy Clin Immunol. 2009 Feb;123(2):443-51. doi: 10.1016/j.jaci.2008.12.1107.

中药治疗食物过敏反应：从动物模型到人体临床试验。

Treatment of food anaphylaxis with traditional Chinese herbal remedies: from mouse model to human clinical trials.

机构信息

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.

出版信息

Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):386-91. doi: 10.1097/ACI.0b013e3283615bc4.

DOI:10.1097/ACI.0b013e3283615bc4
PMID:23799334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4276320/
Abstract

PURPOSE OF REVIEW

To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine.

RECENT FINDINGS

FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges.

SUMMARY

FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies.

摘要

目的综述

描述一种新型食物过敏治疗方法的发展，该方法基于中药，名为食物过敏草药配方-2（FAHF-2）。

最新发现

FAHF-2 已被证明在治疗花生和多种食物过敏的小鼠模型中耐受良好且有效。这些结果伴随着有利的免疫调节的证据，并且在停止治疗后效果仍然持久。早期临床试验表明，该配方在食物过敏个体中具有安全性和耐受性。正在进行的 II 期临床试验将评估 FAHF-2 在保护个体免受口服食物挑战引起的过敏反应中的功效。

总结

FAHF-2 是一种草药配方，具有很高的安全性，已显示可预防食物过敏小鼠模型中的过敏反应。临床试验中的类似发现可能为食物过敏带来新的治疗方法。