三碘化铟催化的通过硅氢烷和有机硅亲核试剂的单步处理实现的酰胺的还原官能化。

Indium triiodide catalyzed reductive functionalization of amides via the single-stage treatment of hydrosilanes and organosilicon nucleophiles.

机构信息

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

出版信息

Org Lett. 2013 Jul 5;15(13):3452-5. doi: 10.1021/ol4015317. Epub 2013 Jun 25.

DOI:10.1021/ol4015317

PMID:23799641

Abstract

The indium triiodide catalyzed single-stage cascade reaction of N-sulfonyl amides with hydrosilanes and two types of organosilicon nucleophiles such as silyl cyanide and silyl enolates selectively promoted deoxygenative functionalization to give α-cyanoamines and β-aminocarbonyl compounds, respectively.

摘要

三碘化铟催化的 N-磺酰基酰胺与硅烷和两种类型的有机硅亲核试剂（如氰基硅烷和硅烯醇酯）的单级级联反应，分别选择性地促进脱氧化官能化，生成α-氰基胺和β-氨基羰基化合物。