吲哚与炔烃和硅烷在铟催化下的还原烷基化反应。
Reductive alkylation of indoles with alkynes and hydrosilanes under indium catalysis.
机构信息
Department of Applied Chemistry, School of Science and Technology, Meiji University, Tama-ku, Kawasaki, Japan.
出版信息
Org Lett. 2011 Mar 4;13(5):912-5. doi: 10.1021/ol1029673. Epub 2011 Jan 26.
PMID:21268645
Abstract
Under Indium catalysis, diverse alkylindoles were successfully prepared with a flexible combination of indoles and alkynes in the presence of hydrosilanes. In addition to the hydrosilane, carbon nucleophiles are also available. This new method generates alkylindoles in yields over 70% with a broad scope of functional group compatibility.
摘要
在铟催化下，吲哚和炔烃在氢硅烷的存在下可以灵活组合，成功制备了多种烷基吲哚。除了氢硅烷之外，还可以使用碳亲核试剂。这种新方法以 70%以上的产率生成烷基吲哚，具有广泛的官能团兼容性。
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