Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
J Gastroenterol Hepatol. 2013 Dec;28(12):1810-4. doi: 10.1111/jgh.12308.
Reddish streaks in an intact stomach are an endoscopic feature of duodenogastric reflux. This study aimed to identify which factors are associated with gastric reddish streaks and thus help prevent mucosal damage from duodenogastric reflux.
Demographic data, personal habits, stressful life events, and psychological distress were compared between subjects with only gastric reddish streaks and those with normal mucosa who underwent upper gastrointestinal endoscopy as part of a self-paid physical checkup. Stress hormones dopamine and cortisol were also checked by high-performance liquid chromatography and radioimmunoassay methods respectively.
There were 95 subjects with gastric reddish streaks and 52 subjects with normal mucosa. No significant differences in age, gender, blood groups, education levels, marital status, religion, aspirin or nonsteroidal anti-inflammatory drug (NSAID) use, smoking habit, alcohol consumption, and intake of tea was found between the two groups, but intake of coffee was borderline more common in subjects with normal mucosa (38.5% vs 22.1%, P = 0.055). Subjects with gastric reddish streaks had lower Helicobacter pylori infection rate (37.8% vs 19.3%, P < 0.05). There were no significant differences in psychological distress and stressful life events between the two groups. Multivariate analysis shows that serum dopamine concentrations (odds ratio = 11.31, 95% confidence interval = 2.11-60.48, P = 0.005) and being without the consumption of coffee (odds ratio = 2.97, 95% confidence interval = 1.27-6.94, P = 0.012) were associated with gastric reddish streaks.
Elevated serum dopamine and less coffee consumption are associated with gastric reddish streaks. These findings implicate that increased dopamine level plays a role for abnormal duodenogastric reflux.
胃内的红色条纹是十二指肠胃反流的内镜特征。本研究旨在确定哪些因素与胃内红色条纹有关，从而有助于预防十二指肠胃反流引起的黏膜损伤。
比较了 95 例仅胃内有红色条纹和 52 例接受自费体检行上消化道内镜检查的正常胃黏膜患者的人口统计学资料、个人习惯、生活应激事件和心理困扰。还分别采用高效液相色谱法和放射免疫法检测应激激素多巴胺和皮质醇。
两组间年龄、性别、血型、受教育程度、婚姻状况、宗教信仰、阿司匹林或非甾体抗炎药（NSAID）使用、吸烟习惯、饮酒、饮茶无显著差异，但正常胃黏膜组咖啡摄入量略高（38.5% vs 22.1%，P = 0.055）。胃内有红色条纹者幽门螺杆菌感染率较低（37.8% vs 19.3%，P < 0.05）。两组间心理困扰和生活应激事件无显著差异。多变量分析显示，血清多巴胺浓度（比值比 = 11.31，95%置信区间 = 2.11-60.48，P = 0.005）和不喝咖啡（比值比 = 2.97，95%置信区间 = 1.27-6.94，P = 0.012）与胃内红色条纹有关。
血清多巴胺升高和咖啡摄入减少与胃内红色条纹有关。这些发现表明，多巴胺水平升高可能在异常十二指肠胃反流中起作用。
