Li Lingnuo, Sun Binlian, Zeng Haiyan, Sun Zhiwu, Sun Guoqing, Yang Rongge
1 Research Group of HIV Molecular Epidemiology and Virology, Center for Emerging Infectious Diseases, The State Key Laboratory of Virology, Wuhan Institute of Virology , Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China .
AIDS Res Hum Retroviruses. 2014 Feb;30(2):160-4. doi: 10.1089/aid.2013.0144. Epub 2013 Jul 24.
To elucidate the prevalence of HIV-1 subtypes and transmitted drug resistance in Henan, central China, HIV-1-positive blood samples from 187 antiretroviral-naive patients were collected in our study from August 2009 to November 2010. Subtype B' (92.0%, 172 of 187) remains the predominant HIV-1 subtype in Henan province and was prevalent in all risk populations and geographic regions. Of 98 pol sequences 67 (68.4%) harbored drug resistance mutations, and only 14 (14.3%, 14 of 98) sequences have mutations associated with significantly reduced phenotypic susceptibility to antiretroviral drugs. The unexpectedly high percentage of drug resistance in Henan province is mainly due to the prevalence of minor mutations in the protease and integrase regions, especially A71T/V and L68V/I/IM/LV. In all, we detected a relatively high prevalence of drug resistance with unique mutation distributions among antiretroviral-naive patients from Henan province.
为阐明中国中部河南省HIV-1亚型的流行情况及传播性耐药情况，我们在2009年8月至2010年11月的研究中收集了187例未接受过抗逆转录病毒治疗的患者的HIV-1阳性血样。B'亚型（92.0%，187例中的172例）仍是河南省主要的HIV-1亚型，在所有风险人群和地理区域中均有流行。在98条pol序列中，67条（68.4%）存在耐药突变，只有14条（14.3%，98条中的14条）序列的突变与抗逆转录病毒药物的表型敏感性显著降低相关。河南省耐药率意外地高，主要是由于蛋白酶和整合酶区域存在少量突变，尤其是A71T/V和L68V/I/IM/LV。总体而言，我们在河南省未接受过抗逆转录病毒治疗的患者中检测到相对较高的耐药率，且存在独特的突变分布。
