在中国中部发现的首例第三代 HIV-1 型循环重组型（CRF114_0155）。
The first third-generation HIV-1 circulating recombinant form (CRF114_0155) identified in central China.
机构信息
Unit of HIV Molecular Epidemiology and Virology, State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Anyang Center for Disease Control and Prevention, Anyang, 455000, China.
出版信息
Arch Virol. 2021 Dec;166(12):3409-3416. doi: 10.1007/s00705-021-05213-9. Epub 2021 Oct 4.
A novel circulating recombinant form (CRF) was identified in eight HIV-1-infected patients without direct epidemiological relationships in Henan Province, Central China. Recombination analysis indicated that the genome of this novel CRF comprises five segments: three inherited from CRF01_AE cluster-4 and two from CRF55_01B. Therefore, the CRF was designated CRF114_0155. It is not only the first novel CRF identified in Henan Province but also the first third-generation CRF of HIV-1 and the first CRF descendant of CRF55_01B. Bayesian inference of phylogeny dated the most recent common ancestor of the CRF114_0155 cluster to 2010. The emergence of CRF114_0155 reflects that the genotype constitution of HIV-1 has become more complex and that stricter intervention measures should be implemented in central China.
在中国中部的河南省，发现了 8 例没有直接流行病学关系的 HIV-1 感染患者的新型循环重组形式（CRF）。重组分析表明，该新型 CRF 的基因组由 5 个片段组成：3 个来自 CRF01_AE 簇-4，2 个来自 CRF55_01B。因此，该 CRF 被命名为 CRF114_0155。这不仅是河南省首次发现的新型 CRF，也是 HIV-1 的首个第三代 CRF，也是 CRF55_01B 的首个 CRF 后代。对系统发育的贝叶斯推断将 CRF114_0155 聚类的最近共同祖先定在 2010 年。CRF114_0155 的出现反映出 HIV-1 的基因型构成变得更加复杂，中国中部地区应采取更严格的干预措施。
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