Takayanagi Yoichiro, Spira Adam P, McIntyre Roger S, Eaton William W
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Am J Geriatr Psychiatry. 2015 Mar;23(3):253-60. doi: 10.1016/j.jagp.2013.02.003. Epub 2013 Jun 22.
Cognitive function in older adults may be affected by multiple factors, such as sex hormone levels, metabolic disturbances, and neuropsychiatric illness. However, relatively few studies have tested the associations between these factors and cognitive function in a single sample. A cross-sectional analysis was conducted to examine the association between sex hormones, metabolic parameters, and psychiatric diagnoses with verbal memory in nondemented older men.
Participants were 112 men (mean age: 61.3 years) from the Baltimore Epidemiologic Catchment Area Follow-Up Study who completed measures of blood sex hormone levels, metabolic parameters (e.g., lipid profiles), and verbal memory.
Higher levels of serum sex hormone binding globulin (SHBG) were associated with lower delayed verbal memory scores (standardized coefficients [beta]=-0.19, t=-2.07, df=1, 105, p=0.04), and higher body mass index (BMI) was associated with better immediate (beta=0.21, t=2.41, df=1,105, p=0.02) and delayed (beta=0.22, t=2.46, df=1,105, p=0.02) verbal memory performance after adjustment for age, education, and psychiatric disorders. There was an inverse correlation between SHBG levels and BMI (Pearson's r=-0.37, N=112, p<0.001). Estimated free testosterone levels revealed curvilinear associations with verbal memory performance.
Our data suggest that higher SHBG levels are associated with worse verbal memory, whereas a higher BMI is associated with better verbal memory in older men. Higher SHBG levels due to lower adiposity may be a risk factor for cognitive dysfunction. The mechanisms linking SHBG to cognitive function have yet to be elucidated.
老年人的认知功能可能受到多种因素的影响，如性激素水平、代谢紊乱和神经精神疾病。然而，相对较少的研究在单个样本中检验这些因素与认知功能之间的关联。进行了一项横断面分析，以研究性激素、代谢参数和精神疾病诊断与未患痴呆症老年男性言语记忆之间的关联。
参与者为来自巴尔的摩流行病学集水区随访研究的112名男性（平均年龄：61.3岁），他们完成了血液性激素水平、代谢参数（如血脂谱）和言语记忆的测量。
血清性激素结合球蛋白（SHBG）水平较高与较低的延迟言语记忆得分相关（标准化系数[β]= -0.19，t = -2.07，自由度=1,105，p = 0.04），在调整年龄、教育程度和精神疾病后，较高的体重指数（BMI）与较好的即时（β= 0.21，t = 2.41，自由度=1,105，p = 0.02）和延迟（β= 0.22，t = 2.46，自由度=1,105，p = 0.02）言语记忆表现相关。SHBG水平与BMI之间存在负相关（皮尔逊r = -0.37，N = 112，p <0.001）。估计的游离睾酮水平与言语记忆表现呈曲线关联。
我们的数据表明，较高的SHBG水平与较差的言语记忆相关，而较高的BMI与老年男性较好的言语记忆相关。较低肥胖导致的较高SHBG水平可能是认知功能障碍的一个危险因素。将SHBG与认知功能联系起来的机制尚未阐明。
