颈段脊髓照射后脊髓炎的发病率。

The incidence of myelitis after irradiation of the cervical spinal cord.

作者信息

Marcus R B, Million R R

机构信息

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32610-0385.

出版信息

Int J Radiat Oncol Biol Phys. 1990 Jul;19(1):3-8. doi: 10.1016/0360-3016(90)90126-5.

DOI:10.1016/0360-3016(90)90126-5

PMID:2380091

Abstract

To further define the tolerance of the cervical spinal cord, the dose of radiation to the cervical spinal cord was calculated for all 2901 patients with malignancies of the upper respiratory tract treated at the University of Florida between October 1964 and December 1987. To further define the population evaluated, certain criteria were used: (a) a minimum of 3000 cGy to at least 2 cm of cervical spinal cord and (b) a minimum of 1 year of follow-up, unless a neurological complication occurred before 1 year. A total of 1112 patients were evaluable, of which 2 (0.18%) developed radiation myelitis. One received 4658 cGy to the cervical cord at 172.5 cGy per day, and the other patient received 4907 cGy to the cord at 169.2 cGy per day. The risk of myelitis at each dose level was 0/124 at 3000-3999 cGy, 0/442 at 4000-4499 cGy, 2/471 at 4500-4999 cGy, and 0/75 at a cord dose of 5000 cGy or greater.

摘要

为进一步明确颈段脊髓的耐受性，我们计算了1964年10月至1987年12月在佛罗里达大学接受治疗的2901例上呼吸道恶性肿瘤患者颈段脊髓的放射剂量。为进一步明确所评估的人群，采用了某些标准：(a) 至少2厘米颈段脊髓接受至少3000 cGy的照射，以及(b) 至少随访1年，除非在1年之前发生神经并发症。共有1112例患者可进行评估，其中2例（0.18%）发生放射性脊髓炎。1例患者颈段脊髓每天接受172.5 cGy，共4658 cGy；另1例患者颈段脊髓每天接受169.2 cGy，共4907 cGy。在每个剂量水平下，脊髓炎的风险在3000 - 3999 cGy时为0/124，在4000 - 4499 cGy时为0/442，在4500 - 4999 cGy时为2/471，在脊髓剂量为5000 cGy或更高时为0/75。