Cardiorenal Med. 2013 Apr;3(1):71-78. doi: 10.1159/000350046.
Periodontal disease is a chronic inflammatory disorder and being so it has been associated with accelerated atherosclerosis and malnutrition. Cardiovascular diseases are the leading cause of mortality in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients [National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases: Annual Data Report, 2010]. A recent scientific statement released by the American Heart Association [Lockhart et al.: Circulation 2012;125:2520-2544] claims that, even though evidence exists to believe that periodontal interventions result in a reduction in systemic inflammation and endothelial dysfunction, there is little evidence that those interventions prevent atherosclerotic vascular disease or modify the outcomes. In this review, we discuss the periodontal findings and their association with an increased prevalence of inflammatory markers and cardiovascular mortality in ESRD patients and CKD.
牙周病是一种慢性炎症性疾病，因此它与动脉粥样硬化和营养不良的加速发展有关。心血管疾病是慢性肾脏病 (CKD) 和终末期肾病 (ESRD) 患者死亡的主要原因[美国国立卫生研究院，美国国立糖尿病、消化和肾脏疾病研究所：年度数据报告，2010]。美国心脏协会最近发布的一份科学声明[Lockhart 等人：Circulation 2012;125:2520-2544]声称，尽管有证据表明牙周干预可降低全身炎症和内皮功能障碍，但几乎没有证据表明这些干预措施可预防动脉粥样硬化性血管疾病或改变其结果。在这篇综述中，我们讨论了牙周病的发现及其与 ESRD 患者和 CKD 中炎症标志物和心血管死亡率增加的相关性。
