Dalbacke J, Dahlquist I, Persson C
Analytical and Quality Development Department, Gacell Laboratories AB, Malmö, Sweden.
J Chromatogr. 1990 May 16;507:381-7. doi: 10.1016/s0021-9673(01)84215-1.
A method for the determination of 0.1 micrograms/l of warfarin in drinking water involving concentration by solid-phase extraction is described. A 1000-ml volume of drinking water is aspirated through a solid-phase extraction column and warfarin is eluted to 1.0 ml. The eluate is analysed by reversed-phase high-performance liquid chromatography with UV detection. The detection limit is 0.02 micrograms/l. Recoveries of greater than 90% were obtained when tap water was spiked with warfarin.
描述了一种通过固相萃取浓缩来测定饮用水中0.1微克/升华法林的方法。吸取1000毫升饮用水通过固相萃取柱，将华法林洗脱至1.0毫升。洗脱液通过带有紫外检测的反相高效液相色谱进行分析。检测限为0.02微克/升。向自来水中添加华法林时，回收率大于90%。
