Ellidag Hamit Yasar, Eren Esin, Aydin Ozgur, Akgol Evren, Yalcinkaya Soner, Sezer Cem, Yilmaz Necat
Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
Asian Pac J Cancer Prev. 2013;14(5):2759-63. doi: 10.7314/apjcp.2013.14.5.2759.
Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI).
Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj- IMA and OSI was calculated.
Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4).
In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.
氧化/抗氧化状态受损在许多疾病（如癌症）的发病机制中起重要作用。本研究旨在评估膀胱癌（BC）患者中新型标志物缺血修饰白蛋白（IMA）和白蛋白校正IMA（Adj-IMA）的水平，以及其与总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）的关联。
本研究纳入了40例男性BC患者（平均年龄67.4±12岁）和40例年龄及性别匹配的健康人（平均年龄56.0±1.7岁）。分析血清IMA、TAS、TOS水平，并计算Adj-IMA和OSI。
与对照组相比，BC患者的血清IMA、TOS和OSI值显著更高（分别为p<0.0001、p=0.01和p=0.01），而BC患者的TAS显著更低（p=0.04）。两组间血清白蛋白校正IMA水平无显著差异（p=0.4）。
本研究发现，BC患者存在氧化/抗氧化状态受损，有利于氧化应激。Adj-IMA计算未证实这一观察结果。目前尚无关于BC患者血清IMA浓度的发表报告。需要进一步研究以确定IMA与BC中氧化应激参数的关系以及IMA对其他癌症的意义。
