Central Laboratories, Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
Gut Liver. 2013 Nov;7(6):675-80. doi: 10.5009/gnl.2013.7.6.675. Epub 2013 Aug 14.
BACKGROUND/AIMS: An impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified albumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).
Forty patients with CRC (19 females and 21 males; mean age, 56.5±2.1 years) and 39 age- and sex-matched healthy people (22 females and 17 males; mean age, 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated.
Serum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32).
In this study, the oxidative/antioxidant status was impaired in favor of oxidative stress in CRC patients. This observation was not confirmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers.
背景/目的：氧化/抗氧化状态受损在许多疾病（包括癌症）的发病机制中起着重要作用。本研究旨在评估新型标志物缺血修饰白蛋白（IMA）和白蛋白校正 IMA（Adj-IMA）在结直肠癌（CRC）患者中的水平，并寻找这些标志物与总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）之间的关联。
本研究纳入了 40 例 CRC 患者（19 名女性和 21 名男性；平均年龄 56.5±2.1 岁）和 39 名年龄和性别匹配的健康人（22 名女性和 17 名男性；平均年龄 56.0±1.7 岁）。分析了血清 IMA、TAS 和 TOS 水平，并计算了 OSI。
CRC 患者的血清 IMA、TOS 和 OSI 水平明显高于对照组（p<0.0001），而 CRC 患者的 TAS 水平明显较低（p=0.03）。两组间血清 Adj-IMA 水平无显著差异（p=0.32）。
在本研究中，CRC 患者的氧化/抗氧化状态受损，有利于氧化应激。这一观察结果未通过 IMA 测量得到证实。需要进一步的研究来确定 IMA 与 CRC 和其他癌症中氧化应激参数之间的关系。
