Ishihara Setsuko, Taira Naruto, Kawasaki Kensuke, Ishibe Youichi, Mizoo Taeko, Nishiyama Keiko, Iwamoto Takayuki, Nogami Tomohiro, Motoki Takayuki, Shien Tadahiko, Matsuoka Junji, Doihara Hiroyoshi, Komoike Yoshifumi, Sato Shuhei, Kanazawa Susumu
Department of Radiology, Okayama Saiseikai General Hospital, Okayama 700-8511, Japan.
Acta Med Okayama. 2013;67(3):145-51. doi: 10.18926/AMO/50407.
A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been performed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, -0.403; p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, -0.196; p value, 0.0143) and number of deliveries (parameter estimate, -0.388; p value, 0.0186) were significant factors determining breast density;breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely correlated with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s.
乳腺钼靶检查显示的高密度被认为是乳腺癌的一个风险因素。然而，关于乳腺密度与生活方式之间关联的研究仅有少数几项。本研究采用了一项包含29个关于生活史和生活方式问题的调查问卷进行横断面研究。乳腺钼靶检查的乳腺密度按照BI-RADS标准分为4类。研究对象为522名无乳腺癌病史的女性。平均年龄为53.3岁。多因素分析显示，在绝经前女性中，只有体重指数（BMI）是决定乳腺密度的显著因素（参数估计值为-0.403；p值为0.0005），且随着BMI升高，乳腺密度降低。在绝经后女性中，BMI（参数估计值为-0.196；p值为0.0143）和分娩次数（参数估计值为-0.388；p值为0.0186）是决定乳腺密度的显著因素；随着BMI和分娩次数增加，乳腺密度降低。仅BMI和分娩次数被确定为显著影响乳腺密度的因素。BMI在绝经前后均与乳腺密度呈负相关，而分娩次数对乳腺密度的影响仅在50多岁和60多岁的绝经后女性中显著。
