Yang Yaping, Liu Jieqiong, Gu Ran, Hu Yue, Liu Fengtao, Yun Miaomiao, Xiao Qiaozhen, Wu Mei, Liu Qiang, Su Fengxi
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Breast Surgery, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Eur J Cancer Prev. 2016 Jul;25(4):306-11. doi: 10.1097/CEJ.0000000000000177.
Mammographic density is an independent strong risk factor for breast cancer. However, the influence of factors on mammographic density in premenopausal women remains unclear. In the Southern Professional Women Breast Cancer Screening Project, we assessed the associations between mammographic density and its influential factors using multivariate logistic regression in premenopausal women adjusting for BMI, age, duration of breastfeeding, number of live births, and breast size. A total of 1699 premenopausal women aged 27 to 57 years, who had been screened by mammography, were enrolled in this cross-sectional study. Overall, 85.2% were categorized as having dense breasts (BI-RADS density 3 and 4) and 14.8% as having fatty breasts (BI-RADS density 1 and 2). In multivariate and logistic regression analysis, only BMI and age were significantly negatively correlated with mammographic density in premenopausal women (P<0.001). No significant associations between mammographic density and number of deliveries, breastfeeding duration, education level, family history of breast cancer, as well as breast size and sleep quality, were identified in the study. Age and BMI are negatively associated with mammographic density in premenopausal Chinese women. Information on the influential factors of mammographic density in premenopausal women might provide meaningful insights into breast cancer prevention.
乳腺钼靶密度是乳腺癌一个独立的强风险因素。然而，绝经前女性中各因素对乳腺钼靶密度的影响仍不明确。在南方职业女性乳腺癌筛查项目中，我们在绝经前女性中采用多因素逻辑回归分析，在校正体重指数（BMI）、年龄、母乳喂养时长、活产次数及乳房大小后，评估乳腺钼靶密度与其影响因素之间的关联。共有1699名年龄在27至57岁之间、接受过乳腺钼靶筛查的绝经前女性纳入了这项横断面研究。总体而言，85.2%的女性被归类为乳房致密（BI-RADS密度3和4级），14.8%的女性被归类为乳房脂肪多（BI-RADS密度1和2级）。在多因素逻辑回归分析中，仅BMI和年龄与绝经前女性的乳腺钼靶密度呈显著负相关（P<0.001）。该研究未发现乳腺钼靶密度与分娩次数、母乳喂养时长、教育水平、乳腺癌家族史以及乳房大小和睡眠质量之间存在显著关联。年龄和BMI与绝经前中国女性的乳腺钼靶密度呈负相关。绝经前女性乳腺钼靶密度影响因素的相关信息可能为乳腺癌预防提供有意义的见解。
