Rice Megan S, Bertrand Kimberly A, Lajous Martin, Tamimi Rulla M, Torres Gabriela, López-Ridaura Ruy, Romieu Isabelle
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Center for Research on Population Health, National Institute of Public Health, Mexico; Center for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale), U1018, Villejuif, France; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA.
Ann Epidemiol. 2015 Nov;25(11):868-73. doi: 10.1016/j.annepidem.2015.08.006. Epub 2015 Aug 29.
Several breast cancer risk factors have been consistently associated with mammographic density (MD); however, data are limited for Hispanic women.
We examined data from 1007 premenopausal and 600 postmenopausal women in the Mexican Teachers' Cohort. Multivariable linear regression was used to estimate associations between risk factors and MD.
Among premenopausal women, age, current body mass index (BMI), BMI at age 18 years, and weight change since age 18 years were inversely associated with percent MD, whereas benign breast disease, alcohol intake, and breastfeeding 12 months or more were associated with higher percent MD. Among postmenopausal women, age, current BMI, BMI at age 18 years, weight change since age 18 years, and speaking or having parents who speak an indigenous language were inversely associated with percent MD, whereas benign breast disease and greater age at natural menopause were positively associated with percent MD. Other breast cancer risk factors, such as age at menarche, parity, and age at first pregnancy, were not significantly associated with density in either premenopausal or postmenopausal women.
Results from the Mexican Teachers' Cohort are generally consistent with predictors of mammographic density observed in primarily non-Hispanic white populations; however, certain risk factors (e.g., parity) were not significantly associated with MD.
多种乳腺癌风险因素一直与乳腺X线密度（MD）相关；然而，关于西班牙裔女性的数据有限。
我们分析了墨西哥教师队列中1007名绝经前女性和600名绝经后女性的数据。采用多变量线性回归来估计风险因素与MD之间的关联。
在绝经前女性中，年龄、当前体重指数（BMI）、18岁时的BMI以及自18岁以来的体重变化与MD百分比呈负相关，而良性乳腺疾病、饮酒以及母乳喂养12个月或更长时间与较高的MD百分比相关。在绝经后女性中，年龄、当前BMI、18岁时的BMI、自18岁以来的体重变化以及说或父母说本土语言与MD百分比呈负相关，而良性乳腺疾病和自然绝经年龄较大与MD百分比呈正相关。其他乳腺癌风险因素，如初潮年龄、生育次数和首次怀孕年龄，在绝经前或绝经后女性中与密度均无显著关联。
墨西哥教师队列的结果总体上与主要在非西班牙裔白人人群中观察到的乳腺X线密度预测因素一致；然而，某些风险因素（如生育次数）与MD无显著关联。
