Neurology Clinic, Clinical Center of Serbia, and School of Medicine, University of Belgrade, 6 Subotica Dr, 11000 Belgrade, Serbia.
J Ultrasound Med. 2013 Jul;32(7):1117-23. doi: 10.7863/ultra.32.7.1117.
New therapeutic strategies under development aim to improve recanalization rates and clinical outcomes after ischemic stroke. One such approach is ultrasound (US)-enhanced thrombolysis, or sonothrombolysis, which can improve thrombolytic drug actions and even intrinsic fibrinolysis. Although the mechanisms are not fully understood, it is postulated that thrombolysis enhancement is related to nonthermal mechanical effects of US. Recent results indicate that US with or without microbubbles may be effective in clot lysis of ischemic stroke even without additional thrombolytic drugs. Sonothrombolysis is a promising tool for treating acute ischemic stroke, but its efficacy, safety, and technical details have not been elucidated and proved yet in stroke treatment.
正在开发的新治疗策略旨在提高缺血性脑卒中后的再通率和临床结局。其中一种方法是超声（US）增强溶栓，也称为声溶栓，它可以增强溶栓药物的作用，甚至增强内源性纤维蛋白溶解。尽管其机制尚未完全阐明，但据推测，溶栓增强与 US 的非热机械效应有关。最近的结果表明，即使没有额外的溶栓药物，超声联合或不联合微泡也可能有效溶解缺血性脑卒中的血栓。声溶栓是治疗急性缺血性脑卒中的有前途的工具，但它在脑卒中治疗中的疗效、安全性和技术细节尚未得到阐明和证实。
