Laboratory of Biomedical Science, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, USA.
Elmezzi Graduate School of Molecular Medicine, 350 Community Drive, Manhasset, NY, USA.
Int Immunol. 2022 Jan 22;34(2):119-128. doi: 10.1093/intimm/dxab073.
The nervous system has been increasingly recognized as a novel and accessible target in the regulation of inflammation. The use of implantable and invasive devices targeting neural circuits has yielded successful results in clinical settings but does have some risk or adverse effects. Recent advances in technology and understanding of mechanistic pathways have opened new avenues of non-invasive neuromodulation. Through this review we discuss the novel research and outcomes of major modalities of non-invasive neuromodulation in the context of inflammation including transcutaneous electrical, magnetic and ultrasound neuromodulation. In addition to highlighting the scientific observations and breakthroughs, we discuss the underlying mechanisms and pathways for neural regulation of inflammation.
神经系统在炎症调节中作为一个新的、可及的靶点，已得到越来越多的认识。针对神经回路的植入式和侵入式设备的使用在临床环境中已取得成功，但确实存在一些风险或不良反应。技术的最新进展和对机械途径的理解为非侵入性神经调节开辟了新途径。通过本次综述，我们讨论了非侵入性神经调节在炎症中的主要模式（包括经皮电、磁和超声神经调节）的新研究和结果。除了突出科学观察和突破外，我们还讨论了神经调节炎症的潜在机制和途径。
