Soriano Vincent, Vispo Eugenia, de Mendoza Carmen, Labarga Pablo, Plaza Zulema, Fernandez-Montero Jose V, Poveda Eva, Treviño Ana, Barreiro Pablo
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
Antivir Ther. 2013;18(8):1033-5. doi: 10.3851/IMP2659. Epub 2013 Jun 27.
Serum HCV RNA rebound beyond 24 weeks after completing hepatitis C therapy has been rarely reported. From 744 patients treated for chronic hepatitis C at our institution, 4 became HCV-RNA-positive again between weeks 36 and 48 post-treatment. Epidemiological and phylogenetic analyses supported very late HCV relapse instead of re-infection in two of them. This observation may have important implications in the pathogenesis and therapeutics of HCV infection.
完成丙型肝炎治疗后24周以上血清HCV RNA反弹的情况鲜有报道。在我们机构接受慢性丙型肝炎治疗的744例患者中，有4例在治疗后第36周至48周之间再次出现HCV RNA阳性。流行病学和系统发育分析支持其中2例为非常晚期的HCV复发而非再感染。这一观察结果可能对HCV感染的发病机制和治疗具有重要意义。
