一种新型无溶剂方法合成含咪唑氮桥杂环。
A novel solvent-free approach to imidazole containing nitrogen-bridgehead heterocycles.
机构信息
Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino Carlo Bo, Via I Maggetti 24, 61029 Urbino (PU), Italy.
出版信息
Org Lett. 2013 Jul 19;15(14):3646-9. doi: 10.1021/ol4015267. Epub 2013 Jun 27.
A very simple domino reaction under solvent-free conditions of various pyridine-like heterocycles with 1,2-diaza-1,3-dienes produces in good yields imidazo[1,2-a]pyridines, imidazo[1,2-a]quinolines, and imidazo[2,1-a]isoquinolines. The advantage of this one-pot transformation lies in the use of simple pyridine-like compounds without prefunctionalization of the starting heterocycles.
在无溶剂条件下，各种吡啶类似物与 1,2-二氮杂-1,3-二烯的非常简单的多米诺反应以良好的收率生成咪唑并[1,2-a]吡啶、咪唑并[1,2-a]喹啉和咪唑并[2,1-a]异喹啉。这种一锅转化的优点在于使用简单的吡啶类似物，而无需对起始杂环进行预官能化。
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