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酗酒者的认知功能与治疗结果

Cognitive functioning and treatment outcome in alcoholics.

作者信息

Alterman A I, Kushner H, Holahan J M

出版信息

J Nerv Ment Dis. 1990 Aug;178(8):494-9.

PMID:2380694
Abstract

The primary objective of this study was to determine whether cognitive functioning at intake into treatment was associated with completion of a 30-day day hospital alcoholism rehabilitation program and 1- and 6-month posttreatment functioning. None of our measures of sociodemographic characteristics, cognitive functioning, and life functioning was found to be significantly correlated with program completion. The measures of cognitive functioning included four cognitive factors--language ability, auditory verbal learning, logical memory, and complex cognitive functioning--as well as an objective measure of within-treatment learning. Canonical correlation analyses were performed to estimate associations among 14 independent variables and seven measures of both 1- and 6-month follow-up outcomes. The independent variables included the five cognitive measures described above, race and age, and seven baseline Addiction Severity Index (ASI) interviewer ratings of severity of alcohol, drug, family/social, legal, medical, employment, and psychological/psychiatric problem levels. The dependent variables at each follow-up evaluation point consisted of the difference between the baseline and follow-up ASI composite (factor) scores in the seven areas of functioning described above. The findings revealed the relative independence of improvement in alcohol problem level at both followup periods, as contrasted with the relative interdependence of the other areas of functioning. Greater baseline alcohol problems and poorer complex cognitive functioning were most consistently associated with improved alcohol-related outcome. Other cognitive measures ere not significantly associated with treatment outcome in the other areas of functioning described above.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本研究的主要目的是确定治疗开始时的认知功能是否与30天日间医院酒精中毒康复项目的完成情况以及治疗后1个月和6个月的功能状况相关。我们发现,社会人口学特征、认知功能和生活功能的各项测量指标均与项目完成情况无显著相关性。认知功能测量指标包括四个认知因素——语言能力、听觉言语学习、逻辑记忆和复杂认知功能——以及治疗期间学习情况的客观测量指标。进行了典型相关分析,以估计14个自变量与1个月和6个月随访结果的7项测量指标之间的关联。自变量包括上述五项认知测量指标、种族和年龄,以及成瘾严重程度指数(ASI)访谈者对酒精、药物、家庭/社会、法律、医疗、就业和心理/精神问题严重程度的7项基线评分。每个随访评估点的因变量由上述七个功能领域中基线和随访时ASI综合(因子)评分的差值组成。研究结果显示,与其他功能领域的相对相互依存性形成对比的是,两个随访期内酒精问题水平改善具有相对独立性。基线时酒精问题越严重且复杂认知功能越差,与酒精相关结果改善的关联最为一致。其他认知测量指标与上述其他功能领域的治疗结果无显著相关性。(摘要截短于250字)

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