抗肿瘤药，178. 从南美植物安的列斯狼尾木中分离出lychnostatins 1和2及其结构

Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana.

作者信息

Pettit G R, Herald D L, Cragg G M, Rideout J A, Brown P

机构信息

Cancer Research Institute, Arizona State University, Tempe 85287.

出版信息

J Nat Prod. 1990 Mar-Apr;53(2):382-90. doi: 10.1021/np50068a017.

DOI:10.1021/np50068a017

PMID:2380713

Abstract

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 micrograms/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.

摘要

采用生物测定法（P388淋巴细胞白血病细胞系）对菊芹提取物的二氯甲烷/甲醇提取物进行分离，得到了两种具有细胞抑制作用的吉马烷型倍半萜内酯（对P - 388细胞的半数有效剂量分别为2.0和0.19微克/毫升），命名为lychnostatins 1 [1]和2 [2]。结构解析最初基于高场（400兆赫）核磁共振和电子轰击质谱分析，并通过X射线晶体结构测定得以明确完成。