抗肿瘤药，162. 葱莲。
Antineoplastic agents, 162. Zephyranthes candida.
作者信息
Pettit G R, Cragg G M, Singh S B, Duke J A, Doubek D L
机构信息
Cancer Research Institute, Arizona State University, Tempe 85287-1604.
出版信息
J Nat Prod. 1990 Jan-Feb;53(1):176-8. doi: 10.1021/np50067a026.
PMID:2348199
Abstract
The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10(-3) micrograms/ml.
摘要
中国药用植物葱莲被发现含有一种具有细胞抑制作用的成分。采用P - 388淋巴细胞白血病生物测定结果指导下对正丁醇提取物进行分离，得到反式二氢石蒜碱[2]作为主要的细胞抑制剂，其半数有效剂量（ED50）为3.2×10^(-3)微克/毫升。
Zotero 插件