Kim D K, Baek N I, Choi S U, Lee C O, Lee K R, Zee O P
Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea.
J Nat Prod. 1997 Nov;60(11):1199-202. doi: 10.1021/np970157d.
In a bioassay-guided search for cytotoxic compounds from higher plants of South Korea, four new sesquiterpenes of the germacranolide type, named cardivins A (1), B (2), C (3), and D (4), have been isolated from the aerial parts of Carpesium divaricatum. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds 1, 2, 3, and 4 showed cytotoxicity to the human tumor cells, A-549 (nonsmall cell lung), SK-OV-3 (ovary), SK-MEL-2 (skin), XF-498 (central nervous system), and HCT-15 (colon).
在一项以生物测定法为导向的从韩国高等植物中寻找细胞毒性化合物的研究中，从山萝卜（Carpesium divaricatum）的地上部分分离出了四种新的吉马烷型倍半萜，命名为心叶素A（1）、B（2）、C（3）和D（4）。这些化合物的结构通过光谱技术得以阐明。化合物1、2、3和4对人肿瘤细胞A-549（非小细胞肺癌）、SK-OV-3（卵巢癌）、SK-MEL-2（皮肤癌）、XF-498（中枢神经系统癌）和HCT-15（结肠癌）显示出细胞毒性。
