抗肿瘤药，107. 从窄叶松蒿中分离出毛蕊花糖苷和异毛蕊花糖苷。
Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia.
作者信息
Pettit G R, Numata A, Takemura T, Ode R H, Narula A S, Schmidt J M, Cragg G M, Pase C P
机构信息
Cancer Research Institute, Arizona State University, Tempe 85287.
出版信息
J Nat Prod. 1990 Mar-Apr;53(2):456-8. doi: 10.1021/np50068a026.
The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.
西南印度马先蒿（Castilleja linariaefolia）产生的提取物对小鼠P - 388（PS）淋巴细胞白血病具有体内活性。以PS细胞系抑制为导向进行分离，得到了细胞毒性化合物，鉴定为已知糖苷毛蕊花糖苷[1]（半数有效剂量2.6微克/毫升）和异毛蕊花糖苷[2]（半数有效剂量10微克/毫升）。通过光谱测量和降解研究确定了这些化合物的结构。在这种植物中还发现了甘露醇。
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