de las Alas V, Geddes L A, Voorhees W D, Bourland J D, Schoenlein W E
University of Michigan Hospitals, Ann Arbor.
J Clin Monit. 1990 Jul;6(3):186-8. doi: 10.1007/BF02832143.
This dog study was designed to identify which of two measurements (oxygen consumption, mean blood pressure) tracked the onset of hyperthermia as reflected by rectal temperature. The animals were anesthetized, paralyzed, and mechanically ventilated. Hyperthermia was induced with 2,4-dinitrophenol (5 mg/kg) injected intravenously in 5 dogs. It was found that the best and earliest predictor of approaching hyperthermia was the increase in oxygen consumption, which increased 10% in 1.72 min. Mean blood pressure was an insensitive indicator of approaching hyperthermia. Rectal temperature, not surprisingly, was found to be a late and undependable early indicator of developing hyperthermia, requiring about 15 minutes to exhibit a definite increase. It is concluded that among these indicators, monitoring oxygen consumption (ml/min) is the most reliable way to identify a metabolic change such as incipient hyperthermia.
这项针对狗的研究旨在确定两种测量指标（耗氧量、平均血压）中的哪一种能够追踪到直肠温度所反映的体温过高的起始阶段。这些动物被麻醉、麻痹并进行机械通气。通过给5只狗静脉注射2,4-二硝基苯酚（5毫克/千克）来诱导体温过高。结果发现，接近体温过高的最佳且最早的预测指标是耗氧量的增加，耗氧量在1.72分钟内增加了10%。平均血压是接近体温过高的不敏感指标。不出所料，直肠温度被发现是体温过高发展的晚期且不可靠的早期指标，需要约15分钟才会出现明显升高。结论是，在这些指标中，监测耗氧量（毫升/分钟）是识别诸如初期体温过高之类的代谢变化的最可靠方法。
