de las Alas V, Voorhees W D, Geddes L A, Bourland J D, Schoenlein W E
University Hospital, Ann Arbor, MI.
J Clin Monit. 1990 Jul;6(3):183-5. doi: 10.1007/BF02832141.
In 4 spontaneously breathing, barbiturate-anesthetized dogs, hyperthermia was induced with 2,4-dinitrophenol while rectal temperature, heart rate, mean blood pressure, end-tidal carbon dioxide, and carbon dioxide production (milliliters per minute) were measured continuously. The latter was determined with a pneumotachygraph (to obtain respired volume) and an infrared carbon dioxide analyzer that measured inspired and expired carbon dioxide concentration. Of the five physiologic measurements, the increase in carbon dioxide production preceded the increase in rectal temperature by more than 120 seconds. End-tidal carbon dioxide was an unreliable indicator in the spontaneously breathing animal of approaching hyperthermia during spontaneous breathing due to a transient tachypnea, which decreased end-tidal carbon dioxide. The carbon dioxide production (milliliters per minute) increased immediately and reached three to five times the control value. Blood pressure and heart rate were insensitive indicators of approaching hyperthermia.
在4只自主呼吸、巴比妥类麻醉的犬中，用2,4-二硝基苯酚诱发体温过高，同时持续测量直肠温度、心率、平均血压、呼气末二氧化碳和二氧化碳产生量（每分钟毫升数）。后者通过呼吸速度描记器（以获得呼吸量）和测量吸入和呼出二氧化碳浓度的红外二氧化碳分析仪来测定。在这五项生理测量中，二氧化碳产生量的增加比直肠温度的增加早120多秒。由于短暂的呼吸急促会降低呼气末二氧化碳，在自主呼吸的动物中，呼气末二氧化碳是接近体温过高的不可靠指标。二氧化碳产生量（每分钟毫升数）立即增加，达到对照值的三到五倍。血压和心率是接近体温过高的不敏感指标。
