Page R L, Meyer R E, Thrall D E, Dewhirst M W
School of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Int J Hyperthermia. 1987 Nov-Dec;3(6):513-25. doi: 10.3109/02656738709140424.
Whole body hyperthermia was induced in older, tumour-bearing dogs using a radiant heat device. Dogs were anaesthetized (thiopental), paralysed (atracurium), and mechanically ventilated (100 per cent O2) during the heating procedure. Heart rate, systolic/diastolic, and mean arterial blood pressure, and arterial blood gases were monitored throughout the procedure. Serum biochemical parameters, complete blood count, and coagulation profiles were evaluated before, during, and after whole body hyperthermia. Significant increases (p less than 0.05) were noted in heart rate, systolic pressure, diastolic pressure, and mean arterial pressure during the treatment period. A significant decrease in arterial oxygen partial pressure due to unknown causes occurred during the treatment period. Clinical evidence of cardiac decompensation was not manifested in any dog following whole body hyperthermia. Total white blood cell count, neutrophil count, alkaline phosphatase, and creatinine kinase were significantly (p less than 0.05) increased 24 h following whole body hyperthermia. These elevations returned to normal within 1 week of treatment in all dogs. Changes in coagulation profiles 24 h following the procedure were not clinically significant. Adequate pretreatment evaluation of cardiovascular, metabolic, and haemostatic function in tumour-bearing dogs is necessary to identify candidates for treatment with systemic hyperthermia. Otherwise healthy, tumour-bearing dogs withstand the physiological stress of whole body hyperthermia without significant acute or persistent toxicity and represent a valuable model for whole body hyperthermia research.
使用辐射加热装置对老年荷瘤犬进行全身热疗。在加热过程中，犬只接受麻醉（硫喷妥钠）、麻痹（阿曲库铵）并进行机械通气（100%氧气）。在整个过程中监测心率、收缩压/舒张压、平均动脉血压和动脉血气。在全身热疗前、期间和之后评估血清生化参数、全血细胞计数和凝血指标。在治疗期间，心率、收缩压、舒张压和平均动脉压显著升高（p<0.05）。在治疗期间，由于不明原因动脉血氧分压显著降低。全身热疗后，没有任何一只犬出现心脏代偿失调的临床证据。全身热疗24小时后，白细胞总数、中性粒细胞计数、碱性磷酸酶和肌酸激酶显著升高（p<0.05）。所有犬只在治疗1周内这些升高指标恢复正常。术后24小时凝血指标的变化在临床上无显著意义。对荷瘤犬的心血管、代谢和止血功能进行充分的预处理评估对于确定全身热疗的候选对象很有必要。否则健康的荷瘤犬能够承受全身热疗的生理应激，且无明显急性或持续性毒性反应，是全身热疗研究的宝贵模型。
