Lamb Elizabeth K, Kao Grace W, Kao Race L
Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Methods Mol Biol. 2013;1036:1-17. doi: 10.1007/978-1-62703-511-8_1.
Cellular cardiomyoplasty is a cell therapy using stem cells or progenitor cells for myocardial regeneration to improve cardiac function and mitigate heart failure. Since we first published cellular cardiomyoplasty in 1989, this procedure became the innovative method to treat damaged myocardium other than heart transplantation. A significant improvement in cardiac function, metabolism, and perfusion is generally observed in experimental and clinical studies, but the improvement is mild and incomplete. Although safety, feasibility, and efficacy have been well documented for the procedure, the beneficial mechanisms remain unclear and optimization of the procedure requires further study. This chapter briefly reviews the stem cells used for cellular cardiomyoplasty and their clinical outcomes with possible improvements in future studies.
细胞心肌成形术是一种利用干细胞或祖细胞进行心肌再生以改善心脏功能和减轻心力衰竭的细胞治疗方法。自1989年我们首次发表关于细胞心肌成形术的文章以来，该手术已成为除心脏移植外治疗受损心肌的创新方法。在实验和临床研究中，通常可观察到心脏功能、代谢和灌注有显著改善，但改善程度轻微且不完全。尽管该手术的安全性、可行性和有效性已有充分记录，但其有益机制仍不清楚，手术的优化还需要进一步研究。本章简要回顾了用于细胞心肌成形术的干细胞及其临床结果，并探讨未来研究中可能的改进方向。
