尼日利亚拉各斯定期献血者的铁储备情况。

Iron stores in regular blood donors in Lagos, Nigeria.

作者信息

Adediran Adewumi, Uche Ebele I, Adeyemo Titilope A, Damulak Dapus O, Akinbami Akinsegun A, Akanmu Alani S

机构信息

Department of Hematology and Blood Transfusion, University of Lagos, Lagos, Nigeria.

出版信息

J Blood Med. 2013 Jun 10;4:75-80. doi: 10.2147/JBM.S42210. Print 2013.

DOI:10.2147/JBM.S42210

PMID:23807865

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3685448/

Abstract

BACKGROUND

Apart from challenging the bone marrow to increase its red cell production, thereby producing more blood for the donor, regular blood donation has been shown to have several benefits, one of which is preventing accumulation of body iron which can cause free radical formation in the body. This study was carried out to assess body iron stores in regular blood donors.

METHODS

A total of 52 regular (study) and 30 first-time (control) volunteer blood donors were studied prospectively. Twenty milliliters of venous blood was drawn from each subject, 5 mL of which was put into sodium ethylenediamine tetra-acetic acid specimen bottles for a full blood count, including red blood cell indices. The remaining sample was allowed to clot in a plain container, and the serum was then retrieved for serum ferritin, serum iron, and serum transferrin receptor measurement by enzyme-linked immunosorbent assay.

RESULTS

Mean hemoglobin and packed cell volume in the study group (13.47 ± 2.36 g/dL and 42.00 ± 7.10, respectively, P = 0.303) were not significantly higher than in the control group (12.98 ± 1.30 g/dL and 39.76 ± 4.41, respectively, P = 0.119). Mean serum ferritin was 102.46 ± 80.26 ng/mL in the control group and 41.46 ± 40.33 ng/mL in the study group (P = 0.001). Mean serum ferritin for women in the study group (28.02 ± 25.00 ng/mL) was significantly lower than for women in the control group (56.35 ± 34.03 ng/mL, P = 0.014). Similarly, men in the study group had a lower mean serum ferritin (48.57 ± 45.17 ng/mL) than men in the control group (145.49 ± 87.74 ng/mL, P = 0.00). The mean serum transferrin receptor value was higher in the study group (1.56 ± 0.88 μg/mL) than in the control group (1.19 ± 0.38 μg/mL, P = 0.033).

CONCLUSION

These findings suggest that hemoglobin concentration, packed cell volume, and serum iron levels are not significantly affected by regular blood donation and that regular blood donors appear to have reduced iron stores compared with controls.

摘要

背景

除了促使骨髓增加红细胞生成，从而为献血者产生更多血液外，定期献血已被证明有诸多益处，其中之一是防止体内铁的蓄积，而铁蓄积会导致体内自由基形成。本研究旨在评估定期献血者的体内铁储备情况。

方法

前瞻性地研究了总共52名定期（研究组）和30名首次（对照组）志愿献血者。从每位受试者抽取20毫升静脉血，其中5毫升放入乙二胺四乙酸钠标本瓶中进行全血细胞计数，包括红细胞指数。其余样本置于普通容器中使其凝固，然后提取血清，通过酶联免疫吸附测定法测量血清铁蛋白、血清铁和血清转铁蛋白受体。

结果

研究组的平均血红蛋白和红细胞压积（分别为13.47±2.36 g/dL和42.00±7.10，P = 0.303）并不显著高于对照组（分别为12.98±1.30 g/dL和39.76±4.41，P = 0.119）。对照组的平均血清铁蛋白为102.46±80.26 ng/mL，研究组为41.46±40.33 ng/mL（P = 0.001）。研究组女性的平均血清铁蛋白（28.02±25.00 ng/mL）显著低于对照组女性（56.35±34.03 ng/mL，P = 0.014）。同样，研究组男性的平均血清铁蛋白（48.57±45.17 ng/mL）低于对照组男性（145.49±87.74 ng/mL，P = 0.00）。研究组的平均血清转铁蛋白受体值（1.56±0.88 μg/mL）高于对照组（1.19±0.38 μg/mL，P = 0.033）。