对 pygmaeocins B 和 C 的对映选择性全合成。

Enantioselective total syntheses of pygmaeocins B and C.

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima, 770-8505, Japan.

出版信息

Org Lett. 2013 Jul 19;15(14):3666-9. doi: 10.1021/ol401543b. Epub 2013 Jun 28.

Abstract

The first enantioselective total syntheses of pygmaeocins B and C have been accomplished using an efficient and highly diastereoselective intramolecular Heck cyclization for the construction of a quaternary stereogenic center and the functionalized A-ring of the natural products as the key step.

摘要

首次采用高效、高非对映选择性的分子内 Heck 环化反应，完成了对映体选择性全合成 pygmaeocins B 和 C，该反应构建了天然产物的季立体中心和官能化 A 环，是关键步骤。