在中国男男性行为者中鉴定出的一种新型HIV-1循环重组型（CRF59_01B）的基因组序列

Genome Sequences of a Novel HIV-1 Circulating Recombinant Form (CRF59_01B) Identified among MSM in China.

作者信息

Li Xingguang, Ning Chuanyi, He Xiang, Yang Yao, Xing Hui, Hong Kunxue, Yang Rongge, Shao Yiming

机构信息

Wuhan Institute of Virology, University of Chinese Academy of Sciences, HIV Molecular Epidemiology and Virology Research Group, The State Key Laboratory of Virology, Xiaohongshan 44, Wuhan, Hubei, Wuhan, Hubei , China, 430071, China CDC, Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, 155 Changbai Road, Changping district, Beijing, Bejing, China, 102206 ;

出版信息

AIDS Res Hum Retroviruses. 2013 Jun 28. doi: 10.1089/AID.2013.0137.

DOI:10.1089/AID.2013.0137

PMID:23809101

Abstract

We report here a novel HIV-1 circulating recombinant form (CRF59_01B), isolated from three epidemiologically unlinked men who have sex with men (MSM) in China. CRF59_01B was composed of subtype CRF01_AE and B, with four identical recombinant breakpoints observed in the pol, env genes and between the 3' tat (or rev) and vpu genes. The emergence of CRF59_01B suggests the increasing significance of homosexual transmission in China's HIV epidemic and may indicate an active transmission network of HIV infections among MSM population in China. Further studies of the molecular epidemiology of HIV-1 epidemic among MSM population in China are necessary to gain a fuller understanding of the transmission network and potential public health impact of HIV -1 among MSM population in this region.

摘要

我们在此报告一种新型的HIV-1循环重组型（CRF59_01B），它是从中国三名在流行病学上无关联的男男性行为者（MSM）中分离出来的。CRF59_01B由CRF01_AE和B亚型组成，在pol、env基因以及3'端tat（或rev）和vpu基因之间观察到四个相同的重组断点。CRF59_01B的出现表明男男性行为在中国HIV流行中的重要性日益增加，可能预示着中国男男性行为人群中存在活跃的HIV感染传播网络。有必要对中国男男性行为人群中HIV-1流行的分子流行病学进行进一步研究，以更全面地了解该地区男男性行为人群中HIV-1的传播网络及其潜在的公共卫生影响。