在中国吉林省男男性行为者中检测到的一种新型HIV-1重组形式（CRF01_AE/B）的近乎全长基因组序列。
Near full-length genome sequence of a novel HIV-1 recombinant form (CRF01_AE/B) detected among men who have sex with men in Jilin Province, China.
作者信息
Li Xingguang, Feng Yi, Yang Yao, Chen Yanli, Guo Qi, Sun Liuyan, Zang Xihui, Xing Hui, Shao Yiming
机构信息
1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
出版信息
AIDS Res Hum Retroviruses. 2014 Jul;30(7):701-5. doi: 10.1089/aid.2014.0008. Epub 2014 Mar 6.
We report here a novel HIV-1 recombinant form (CRF01_AE/B) detected from a comprehensive HIV-1 molecular epidemiologic study among men who have sex with men (MSM) in Jilin province of northeastern China. The near full-length genome (NFLG) analyses showed that the novel HIV-1 recombinant isolate (JL.RF07) was composed of CRF01_AE cluster 5 (northeastern China origin) and subtype B (U.S. and European origin), with six recombinant breakpoints observed in the pol, vif, tat, rev, and env gene regions. To the best of our knowledge, this is the first detection of a novel HIV-1 recombinant form (CRF01_AE/B) in Jilin, which may indicate an active transmission network of HIV-1 infection among MSM in the region. Further studies of the molecular epidemiology of the HIV-1 epidemic among MSM in northeastern China are necessary to gain a fuller understanding of the transmission network and potential public health impact of HIV-1 among MSM in this region.
我们在此报告一种新型HIV-1重组形式（CRF01_AE/B），它是在中国东北吉林省开展的一项针对男男性行为者（MSM）的全面HIV-1分子流行病学研究中检测到的。近乎全长基因组（NFLG）分析表明，这种新型HIV-1重组毒株（JL.RF07）由CRF01_AE簇5（源自中国东北）和B亚型（源自美国和欧洲）组成，在pol、vif、tat、rev和env基因区域观察到六个重组断点。据我们所知，这是在吉林首次检测到新型HIV-1重组形式（CRF01_AE/B），这可能表明该地区MSM中存在活跃的HIV-1感染传播网络。有必要对中国东北MSM中HIV-1流行的分子流行病学开展进一步研究，以便更全面地了解该地区MSM中HIV-1的传播网络及其潜在的公共卫生影响。
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