Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A.A. 678, Bucaramanga, Colombia.
Chem Biol Drug Des. 2013 Nov;82(5):477-99. doi: 10.1111/cbdd.12180. Epub 2013 Aug 9.
Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006-2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.
对基于斑蝥素的小分子的化学和药理学信息进行了分析。该综述总结了 2006-2012 年期间有关斑蝥昆虫代谢物的新事实。本文对基于斑蝥素的小分子的一般合成方法以及与斑蝥素、去斑蝥素、斑蝥酰胺和去斑蝥酰胺类似物相关的化学转化和生物活性进行了讨论，特别是它们在癌症治疗中对磷酸蛋白磷酸酶的抑制活性，这有助于设计其他生物模型的新型小分子调节剂。
