新生儿生命中的代谢组学。

Metabolomics in neonatal life.

机构信息

Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Italy.

出版信息

Early Hum Dev. 2013 Jun;89 Suppl 1:S7-10. doi: 10.1016/S0378-3782(13)70003-3.

Abstract

Metabolomics (or metabonomics) is based on the systematic study of the complete set of metabolites in a biological sample and is considered the most innovative of the 'omics' sciences. The metabolome is currently regarded as the 'new clinical biochemistry' it is the most predictive phenotype, through consideration of epigenetic differences. Among more than 5000 papers listed in PubMed on this topic in the last three years, less than 60 refer to neonatal life. Aim of this review is to present the clinical applications of metabolomics in neonatology, including results of recent studies performed in experimental models and newborns.

摘要

代谢组学（或代谢组学）基于对生物样本中全套代谢物的系统研究，被认为是“组学”科学中最具创新性的学科。代谢组学目前被认为是“新的临床生物化学”，它是最具预测性的表型，通过考虑表观遗传差异。在过去三年中，PubMed 上关于这个主题的 5000 多篇论文中，只有不到 60 篇涉及新生儿期。本综述旨在介绍代谢组学在新生儿学中的临床应用，包括在实验模型和新生儿中进行的最新研究结果。