钙调神经磷酸酶依赖性离子通道在心脏中的调节。
Calcineurin-dependent ion channel regulation in heart.
机构信息
Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Pediatrics, Emory University, Atlanta, GA, USA.
Department of Internal Medicine (Cardiology), University of Texas, Southwestern Medical Center, Dallas, TX, USA.
出版信息
Trends Cardiovasc Med. 2014 Jan;24(1):14-22. doi: 10.1016/j.tcm.2013.05.004. Epub 2013 Jul 1.
Abstract
Calcineurin, a serine-threonine-specific, Ca(2+)-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (Ito) and L-type calcium current (ICa,L). We go on to discuss unanswered questions that surround these observations and provide perspective on future directions in this exciting field.
摘要
钙调神经磷酸酶是一种从酵母到人类都保守的丝氨酸-苏氨酸特异性、Ca(2+)-钙调蛋白激活的蛋白磷酸酶，在调节心脏发育、肥大和病理性重塑方面发挥着关键作用。最近的研究表明，钙调神经磷酸酶以一种经常涉及与这些靶蛋白直接相互作用的方式调节心肌细胞的离子通道和受体。在这里，我们综述了钙调神经磷酸酶调节心肌离子通道的最新知识状态，重点讨论了瞬时外向钾电流（Ito）和 L 型钙电流（ICa,L）。我们接着讨论了这些观察结果所围绕的未解决的问题，并为这一令人兴奋的领域的未来方向提供了视角。
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