硅胶囊多孔聚乙烯球形植入物的血管化和暴露率：动物模型。
Rate of vascularization and exposure of silicone-capped porous polyethylene spherical implants: an animal model.
机构信息
*Department of Ophthalmology, Wilford Hall Medical Center, San Antonio, Texas; †Department of Oculofacial Plastic Surgery, Ophthalmic Surgeons and Consultants of Ohio, Columbus, Ohio; ‡Section Oculofacial Plastic Surgery, Ohio University/OhioHealth Doctors Hospital, Columbus, Ohio; and §Department of Ophthalmology, The Ohio State University, Columbus, Ohio, U.S.A.
出版信息
Ophthalmic Plast Reconstr Surg. 2013 Sep-Oct;29(5):350-6. doi: 10.1097/IOP.0b013e318295f9c1.
PURPOSE
This pilot study examines the rates of exposure and fibrovascular ingrowth of silicone-capped, porous, polyethylene orbital implants in the New Zealand white rabbit animal model.
METHODS
Unwrapped, silicone-capped, porous, polyethylene orbital spheres were implanted in 16 enucleated rabbit orbits. Four implants were removed at 3, 6, 9, and 12-month intervals and submitted for histopathologic analysis. A board-certified pathologist reviewed and graded vascular ingrowth, inflammation type, and severity for all specimens.
RESULTS
Fibrovascular ingrowth in the center of all implants occurred as early as 3 months. No fibrovascular ingrowth occurred at the interface between the silicone cap and the porous polyethylene implant. The overlying Tenon's and conjunctival tissues remained intact without significant host inflammatory response. No implant exposure occurred at any time point.
CONCLUSIONS
Silicone-capped porous polyethylene orbital implants appear to offer an inexpensive, easy-to-manufacture implant that resists exposure without the need for a wrapping material and achieves successful biointegration soon after implantation.
目的
本初步研究旨在探讨硅帽多孔聚乙烯眼眶植入物在新西兰白兔动物模型中的暴露率和纤维血管内生长情况。
方法
将未包裹的硅帽多孔聚乙烯眼眶球体植入 16 只去眼球兔眼眶内。在 3、6、9 和 12 个月时分别取出 4 个植入物，进行组织病理学分析。一名经董事会认证的病理学家对所有标本的血管内生长、炎症类型和严重程度进行了审查和分级。
结果
所有植入物中心的纤维血管内生长早在 3 个月时就已发生。硅帽与多孔聚乙烯植入物之间的界面没有纤维血管内生长。上方的腱膜和结膜组织保持完整，没有明显的宿主炎症反应。在任何时间点都没有发生植入物暴露。
结论
硅帽多孔聚乙烯眼眶植入物似乎提供了一种廉价、易于制造的植入物，它具有抗暴露的能力，不需要包裹材料，并且在植入后很快就能成功实现生物整合。
Zotero 插件