Synthesis, antimicrobial and cytotoxic activities of sulfonamidomethane linked heterocycles.

作者信息

Swapna Mukkara, Premakumari Chokkappagari, Reddy Sanapalli Nagi, Padmaja Adivireddy, Padmavathi Venkatapuram, Kondaiah Paturu, Krishna Narra Siva

机构信息

Department of Chemistry, Sri Venkateswara University, Tirupati–517 502, Andhra Pradesh, India.

出版信息

Chem Pharm Bull (Tokyo). 2013;61(7):722-30. doi: 10.1248/cpb.c13-00218.

DOI:10.1248/cpb.c13-00218

PMID:23812397

Abstract

A new class of sulfonamidomethane pyrrolyl-oxadiazoles/thiadiazoles and pyrazolyl-oxadiazoles/thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penicillium chrysogenum. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.

摘要

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