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股骨髋臼撞击症:透明质酸是否有效?

Femoroacetabular impingement: is hyaluronic acid effective?

作者信息

Abate Michele, Scuccimarra Tommaso, Vanni Daniele, Pantalone Andrea, Salini Vincenzo

机构信息

Department of Medicine and Science of Aging, University G. d'Annunzio Chieti-Pescara, Via dei Vestini 31, 66013, Chieti Scalo, CH, Italy,

出版信息

Knee Surg Sports Traumatol Arthrosc. 2014 Apr;22(4):889-92. doi: 10.1007/s00167-013-2581-1. Epub 2013 Jun 28.

Abstract

PURPOSE

Femoroacetabular impingement may predispose to the development of hip osteoarthritis. Conservative treatments are effective in the short term, but surgery is often required. Aim of this paper was to report the short-term results on hip pain and function after ultrasound-guided injections of hyaluronic acid.

METHODS

In this open prospective trial, twenty patients suffering from mild femoroacetabular impingement were enrolled. Each patient received a 2-ml intra-articular ultrasound-guided injection of hyaluronic acid at baseline and after 40 days; the same dosing schedule was repeated after 6 months. The clinical evaluation was performed at baseline and after 6 and 12 months of follow-up. Pain score, Lequesne Index, Harris Hip Score and anti-inflammatory medication consumption were measured. Adverse events were also registered.

RESULTS

Twenty-three hips (3 bilateral cases) were treated. Pain decreased from 6.7 ± 1.3 to 3.7 ± 1.8 and to 1.7 ± 1.8 after 6 and 12 months, respectively; Lequesne Index was reduced and the mean Harris Hip Score improved from 83.3 ± 6 before treatment to 88.2 ± 4.7 at 12 months. Consumption of anti-inflammatory drugs was also reduced, from 14 to 4 subjects and from 3.6 ± 2.2 to 1.3 ± 1.3 tablets/week. Local side effects after injection were observed only in 2 cases.

CONCLUSIONS

Hyaluronic acid is safe and effective in the treatment of mild femoroacetabular impingement, with significant pain reduction and function improvement.

摘要

目的

股骨髋臼撞击症可能易导致髋关节骨关节炎的发生。保守治疗在短期内有效,但通常需要手术治疗。本文旨在报告超声引导下注射透明质酸后髋关节疼痛和功能的短期疗效。

方法

在这项开放性前瞻性试验中,纳入了20例轻度股骨髋臼撞击症患者。每位患者在基线时和40天后接受2毫升超声引导下关节内注射透明质酸;6个月后重复相同的给药方案。在基线时以及随访6个月和12个月后进行临床评估。测量疼痛评分、勒凯斯内指数、哈里斯髋关节评分和抗炎药物的使用情况。还记录了不良事件。

结果

共治疗了23个髋关节(3例双侧病例)。疼痛在6个月和12个月后分别从6.7±1.3降至3.7±1.8和1.7±1.8;勒凯斯内指数降低,平均哈里斯髋关节评分从治疗前的83.3±6提高到12个月时的88.2±4.7。抗炎药物的使用也减少了,使用药物的患者从14例降至4例,每周用药片数从3.6±2.2降至1.3±1.3。仅2例观察到注射后的局部副作用。

结论

透明质酸治疗轻度股骨髋臼撞击症安全有效,能显著减轻疼痛并改善功能。

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