Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, 3015 CE Rotterdam, The Netherlands.
Rev Med Virol. 2013 Sep;23(5):295-304. doi: 10.1002/rmv.1751. Epub 2013 Jul 1.
Hepatitis E virus (HEV) infection has emerged as a global public health issue. Although it often causes an acute and self-limiting infection with low mortality rates in the western world, it bears a high risk of developing chronic hepatitis in immunocompromised patients with substantial mortality rates. Organ transplant recipients who receive immunosuppressive medication to prevent rejection are thought to be the main population at risk for chronic hepatitis E. Therefore, there is an urgent need to properly evaluate the clinical impact of HEV in these patients. This article aims to review the prevalence, infection course, and management of HEV infection after solid organ transplantation by performing a comprehensive literature review. In addition, an in-depth emphasis of this clinical issue and a discussion of future development are also presented.
戊型肝炎病毒 (HEV) 感染已成为全球公共卫生问题。虽然在西方世界，它通常引起急性和自限性感染，死亡率较低，但在免疫功能低下的患者中，它有发展为慢性肝炎的高风险，死亡率很高。接受免疫抑制药物以预防排斥反应的器官移植受者被认为是慢性乙型肝炎的主要高危人群。因此，迫切需要对这些患者的 HEV 临床影响进行适当评估。本文通过全面文献回顾，旨在综述实体器官移植后 HEV 感染的流行率、感染过程和管理。此外，还深入强调了这一临床问题，并讨论了未来的发展方向。
