Suyajna D Joshi, Cm Veerendrakumar
Professor & Head, Department of Obstetrics & Gynaecology, Head Quarter Hospital, Ananthpur Road Vijayanagara Institute of Medical Sciences (VIMS) , Bellary-583101, Karnataka, India .
J Clin Diagn Res. 2013 May;7(5):868-72. doi: 10.7860/JCDR/2013/5398.2961. Epub 2013 Mar 25.
To determine the efficacy and the safety of the single dose MgSo4 ('VIMS') regimen in treating eclamptic seizures and their effect on the maternal and foetal outcomes.
A prospective, observational study was conducted in the period from 2003 to 2007. 513 eclamptic women who were admitted to the Dept of OBG, VIMS, Bellary, received single doses of 4g diluted 50% Mgso4 intravenously, with simultaneous 4g 50% MgSo4 intramuscularly. The recurrent seizures, maternal mortality and the perinatal mortality were measured.
9.16% of recurrence (11.66%-16.49%), 3.3% of maternal mortality (1.8%-4.9%) and 24.8 % ( 21.1%-28.7%) of perinatal mortality were observed. The statistical analysis was done by using confidence intervals, standard deviations, means and the Standard normal "Z" test.
The single dose MgSo4 regimen is effective and safe in controlling eclamptic convulsions. The 'VIMS' regimen can be used at First Referral Units, before shifting the patients to tertiary care centres. This approach has special implications in the developing countries, especially at the primary care level, where the standard obstetric care is not widely available.
确定单剂量硫酸镁（“VIMS”方案）治疗子痫抽搐的疗效和安全性及其对母婴结局的影响。
于2003年至2007年进行了一项前瞻性观察研究。513名单独收治于贝拉里VIMS妇产科的子痫妇女接受了静脉注射4g稀释的50%硫酸镁单剂量，同时肌肉注射4g 50%硫酸镁。测量复发性抽搐、孕产妇死亡率和围产期死亡率。
观察到复发率为9.16%（11.66%-16.49%），孕产妇死亡率为3.3%（1.8%-4.9%），围产期死亡率为24.8%（21.1%-28.7%）。采用置信区间、标准差、均值和标准正态“Z”检验进行统计分析。
单剂量硫酸镁方案在控制子痫惊厥方面有效且安全。“VIMS”方案可在一级转诊单位使用，然后再将患者转诊至三级护理中心。这种方法在发展中国家具有特殊意义，尤其是在初级保健层面，那里标准的产科护理并不广泛可用。
