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本文引用的文献

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Alternative regimens of magnesium sulfate for treatment of preeclampsia and eclampsia: a systematic review of non-randomized studies.硫酸镁治疗子痫前期和子痫的替代方案：非随机研究的系统评价
Acta Obstet Gynecol Scand. 2016 Feb;95(2):144-56. doi: 10.1111/aogs.12807. Epub 2015 Nov 8.
2
An evaluation of serum magnesium status in pre-eclampsia compared to the normal pregnancy.与正常妊娠相比，子痫前期患者血清镁水平的评估。
Mymensingh Med J. 2014 Oct;23(4):649-53.
3
Global causes of maternal death: a WHO systematic analysis.全球孕产妇死亡原因：世卫组织系统分析。
Lancet Glob Health. 2014 Jun;2(6):e323-33. doi: 10.1016/S2214-109X(14)70227-X. Epub 2014 May 5.
4
Comparison of Maternal Serum Magnesium Level in Pre-eclampsia and Normal Pregnant Women.子痫前期孕妇与正常孕妇血清镁水平的比较。
Iran Red Crescent Med J. 2013 Dec;15(12):e10394. doi: 10.5812/ircmj.10394. Epub 2013 Dec 5.
5
Pre-eclampsia, eclampsia and adverse maternal and perinatal outcomes: a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health.子痫前期、子痫和不良母婴围产结局：世界卫生组织母婴健康调查的二次分析。
BJOG. 2014 Mar;121 Suppl 1:14-24. doi: 10.1111/1471-0528.12629.
6
'Single Dose MgSo4 Regimen' for Eclampsia - A Safe Motherhood Initiative.用于子痫的“单剂量硫酸镁方案”——一项安全孕产倡议
J Clin Diagn Res. 2013 May;7(5):868-72. doi: 10.7860/JCDR/2013/5398.2961. Epub 2013 Mar 25.
7
Experience of a low-dose magnesium sulfate regimen for the management of eclampsia over a decade.十多年来低剂量硫酸镁方案治疗子痫的经验。
Int J Gynaecol Obstet. 2013 Jul;122(1):13-7. doi: 10.1016/j.ijgo.2013.01.029. Epub 2013 Apr 12.
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Effect of maternal body mass index on serum magnesium levels given for seizure prophylaxis.母体体重指数对预防癫痫发作时给予的血清镁水平的影响。
Obstet Gynecol. 2013 Feb;121(2 Pt 1):314-320. doi: 10.1097/AOG.0b013e31827d90cc.
9
Low-dose magnesium sulphate in the control of eclamptic fits: a randomized controlled trial.低剂量硫酸镁控制子痫发作的随机对照试验。
Arch Gynecol Obstet. 2013 Jan;287(1):43-6. doi: 10.1007/s00404-012-2523-z. Epub 2012 Aug 29.
10
The efficacy of intramuscular loading dose of MgSO4 in severe pre-eclampsia/ eclampsia at a tertiary referral centre in Northwest Nigeria.尼日利亚西北部一家三级转诊中心肌肉注射负荷剂量硫酸镁治疗重度子痫前期/子痫的疗效
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单次负荷低剂量硫酸镁方案：印度女性替代普里查德方案的一种简单、安全且有效的选择。

Single Loading Low Dose MgSo Regimen: A Simple, Safe and Effective Alternative to Pritchard's Regimen for Indian Women.

作者信息

Nagaria Tripti, Mitra Subarna, Banjare Sashi Prabha

机构信息

Professor, Department of Obstetrics and Gynaecology, Pt. Jawaharlal Nehru Medical College and Hospital, Raipur, Chhattisgarh, India.

Assistant Professor, Department of Obstetrics and Gynaecology, Pt. Jawaharlal Nehru Medical College and Hospital, Raipur, Chhattisgarh, India.

出版信息

J Clin Diagn Res. 2017 Aug;11(8):QC08-QC12. doi: 10.7860/JCDR/2017/26635.10453. Epub 2017 Aug 1.

DOI:10.7860/JCDR/2017/26635.10453
PMID:28969211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5620852/
Abstract

INTRODUCTION

Magnesium sulphate is the anticonvulsant of choice in prevention and control of eclamptic convulsions. Pritchard's regimen is the most popular time-tested regimen used. However, owing to concerns of toxicity, several low dose regimens have been introduced considering the lower body mass index of Asian women.

AIM

To compare the efficacy and safety of a single loading low dose MgSo regimen with the Pritchard's regimen.

MATERIALS AND METHODS

Seventy cases of eclampsia and imminent eclampsia were allocated to the control and study groups each. The former received the Pritchard's regimen while the latter was treated with single loading low dose of magnesium sulphate. Recurrent convulsion rates, maternal and perinatal outcomes of both regimens were evaluated and compared using unpaired t-test and Chi-square test for continuous and categorical variables, respectively.

RESULTS

The mean serum magnesium levels were significantly lower in the study group at 30 minutes and 4 hours of initiation of therapy. The single loading low dose regimen was equally efficacious in prevention (96.6% vs 100%, p = 0.934) and control (97.6% vs 97.8%, p = 0.358) of eclamptic fits as compared to the Pritchard's regimen. The feto-maternal outcomes were also comparable.

CONCLUSION

The single loading low dose MgSo regimen is an effective and safe alternative to the Pritchard's regimen, especially tailored to the small built Indian women.

摘要

引言

硫酸镁是预防和控制子痫抽搐的首选抗惊厥药物。普里查德方案是最常用且经过时间检验的方案。然而，由于对毒性的担忧，考虑到亚洲女性较低的体重指数，已引入了几种低剂量方案。

目的

比较单次负荷低剂量硫酸镁方案与普里查德方案的疗效和安全性。

材料与方法

将70例子痫和先兆子痫患者分别分配至对照组和研究组。前者接受普里查德方案治疗，而后者接受单次负荷低剂量硫酸镁治疗。分别使用独立样本t检验和卡方检验对两种方案的复发抽搐率、孕产妇和围产儿结局进行评估和比较，连续变量和分类变量分别采用这两种检验方法。

结果

在治疗开始30分钟和4小时时，研究组的平均血清镁水平显著较低。与普里查德方案相比，单次负荷低剂量方案在预防（96.6%对100%，p = 0.934）和控制（97.6%对97.8%，p = 0.358）子痫发作方面同样有效。母婴结局也相当。

结论

单次负荷低剂量硫酸镁方案是普里查德方案的一种有效且安全的替代方案，尤其适用于身材瘦小的印度女性。