Van der Zee C E, Schuurman T, van der Hoop R G, Traber J, Gispen W H
Rudolf Magnus Institute, University of Utrecht, The Netherlands.
Neurobiol Aging. 1990 Jul-Aug;11(4):451-6. doi: 10.1016/0197-4580(90)90012-o.
In aged rats neuromuscular function and motor coordination is gradually impaired. Major motor deficits were seen in rats of more than 2 years of age; with increasing age, the incidence of abnormal footprints increased sharply. Oral nimodipine, a Ca2(+)-entry blocker of the dihydropyridine type, treatment suppressed and/or delayed the appearance of these abnormal footprints. In aged rats that already displayed a considerable amount of abnormal footprints in the free walking pattern, oral nimodipine treatment was similarly effective. Nimodipine not only delays the onset of age-related motor deficits, but also may counteract these deficits once already present. In aged rats the nerve conduction velocities were severely diminished. Nimodipine treatment resulted in an enhancement of the sciatic and caudal nerve conduction velocities. Histological analysis revealed a lower fiber density in aged rats compared to aged nimodipine-treated rats. Whether nimodipine acts directly on the peripheral nervous system is currently unclear. Nevertheless, the present study lends further support for the beneficial effects of nimodipine in age-related motor deficits in the rat.
在老年大鼠中，神经肌肉功能和运动协调性会逐渐受损。在2岁以上的大鼠中可观察到明显的运动缺陷；随着年龄的增长，异常足迹的发生率急剧增加。口服尼莫地平（一种二氢吡啶类钙离子通道阻滞剂）治疗可抑制和/或延缓这些异常足迹的出现。在自由行走模式中已经出现大量异常足迹的老年大鼠中，口服尼莫地平治疗同样有效。尼莫地平不仅能延缓与年龄相关的运动缺陷的发生，而且一旦出现这些缺陷，还可能抵消它们。老年大鼠的神经传导速度严重降低。尼莫地平治疗可提高坐骨神经和尾神经的传导速度。组织学分析显示，与接受尼莫地平治疗的老年大鼠相比，未治疗的老年大鼠纤维密度较低。目前尚不清楚尼莫地平是否直接作用于外周神经系统。然而，本研究进一步支持了尼莫地平对大鼠与年龄相关的运动缺陷具有有益作用的观点。
