van der Zee C E, Schuurman T, Traber J, Gispen W H
Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, University of Utrecht, The Netherlands.
Neurosci Lett. 1987 Dec 16;83(1-2):143-8. doi: 10.1016/0304-3940(87)90231-x.
Oral administration of the Ca2+-entry blocker nimodipine accelerates in a dose-dependent manner the recovery of sensorimotor function following a crush lesion of the rat sciatic nerve. The beneficial effect of nimodipine was apparent in both a foot shock withdrawal test and in a test analyzing the walking pattern of the rat. These data are the first demonstration of nimodipine-induced enhanced recovery following peripheral nerve damage.
口服钙离子通道阻滞剂尼莫地平，能以剂量依赖的方式加速大鼠坐骨神经挤压损伤后感觉运动功能的恢复。在足部电击撤离试验和分析大鼠行走模式的试验中，尼莫地平的有益效果均很明显。这些数据首次证明了尼莫地平能促进周围神经损伤后的恢复。
