经腹膜给予溶解氢用于腹膜透析患者：一种抑制腹膜腔氧化应激的新方法。
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
作者信息
Terawaki Hiroyuki, Hayashi Yoshimitsu, Zhu Wan-Jun, Matsuyama Yukie, Terada Tomoyoshi, Kabayama Shigeru, Watanabe Tsuyoshi, Era Seiichi, Sato Bunpei, Nakayama Masaaki
机构信息
Dialysis Center, Fukushima Medical University, Fukushima, Japan.
出版信息
Med Gas Res. 2013 Jul 1;3(1):14. doi: 10.1186/2045-9912-3-14.
BACKGROUND
Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS using albumin redox state as a marker.
METHODS
Effluent and blood samples of 6 regular PD patients were obtained during the peritoneal equilibrium test using standard dialysate and hydrogen-enriched dialysate. The redox state of albumin in effluent and blood was determined using high-performance liquid chromatography.
RESULTS
Mean proportion of reduced albumin (ƒ(HMA)) in effluent was significantly higher in H2-enriched dialysate (62.31 ± 11.10%) than in standard dialysate (54.70 ± 13.08%). Likewise, serum ƒ(HMA) after administration of hydrogen-enriched dialysate (65.75 ± 7.52%) was significantly higher than that after standard dialysate (62.44 ± 7.66%).
CONCLUSIONS
Trans-peritoneal administration of H2 reduces peritoneal and systemic OS.
背景
据报道，与甲基乙二醛等葡萄糖降解产物相关的氧化应激（OS）与接受腹膜透析（PD）治疗的患者的腹膜恶化有关。然而，由于其有害影响，一般抗氧化剂的使用受到限制。本研究旨在以白蛋白氧化还原状态为标志物，阐明新型抗氧化剂分子氢（H₂）对腹膜氧化应激的影响。
方法
在腹膜平衡试验期间，使用标准透析液和富氢透析液采集6例常规腹膜透析患者的流出液和血液样本。使用高效液相色谱法测定流出液和血液中白蛋白的氧化还原状态。
结果
富氢透析液组流出液中还原型白蛋白的平均比例（ƒ（HMA））（62.31±11.10%）显著高于标准透析液组（54.70±13.08%）。同样，给予富氢透析液后血清ƒ（HMA）（65.75±7.52%）显著高于给予标准透析液后（62.44±7.66%）。
结论
经腹膜给予H₂可减轻腹膜和全身的氧化应激。
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